Imaging proliferation of ¹⁸F-FLT PET/CT correlated with the expression of microvessel density of tumour tissue in non-small-cell lung cancer.

European Journal of Nuclear Medicine and Molecular Imaging
Wenfeng YangJinming Yu

Abstract

The aim of this study was to analyse the correlation between (18)F-labelled 3'-deoxy-3'-fluorothymidine ((18)F-FLT) PET/CT proliferation images and tumour angiogenesis as reflected by intratumoral microvessel density (MVD) in non-small-cell lung cancer (NSCLC) to provide a noninvasive method to predict the response to antiangiogenic therapy. A total of 68 patients with proven or suspected NSCLC underwent FLT PET/CT scans followed by surgery. PET/CT images were compared with pathology. Tumour proliferation was evaluated in terms of a Ki-67 labelling index (Ki-67 LI). MVD was determined using an anti-CD31 mAb (CD31-MVD), anti-CD34 mAb (CD34-MVD) and an anti-CD105 mAb (CD105-MVD) for each resected tumour. Tumour FLT maximum standardized uptake values (SUVmax) were significantly correlated with the Ki-67 LI and CD105-MVD (r = 0.550 and 0.633, P = 0.000 and 0.000, respectively), but were only marginally correlated with the CD31-MVD and CD34-MVD (r = 0.228 and 0.235, P = 0.062 and 0.054, respectively). The FLT PET false-negative patients had a longer median survival time than the FLT PET true-positive patients (log rank test, P = 0.012). The patients with a lower CD105-MVD had a longer median survival time than those with a higher CD...Continue Reading

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 1, 1996·The Journal of Pathology·P KumarC Bernabeu
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
May 4, 1999·International Journal of Cancer. Journal International Du Cancer·D W MillerJ Adamkiewicz
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M LiaoD Zhu
Apr 3, 2002·European Journal of Nuclear Medicine and Molecular Imaging·W MierM Eisenhut
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Marc HickesonAbass Alavi
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S StroobantsA van Oosterom
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph PöttgenMartin Stuschke
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giuseppe Giaccone
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Oct 3, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Yuka YamamotoMotoomi Ohkawa
Jan 8, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wenfeng YangWanhu Li
Jan 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jiahe TianWenkai Wu
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roland UllrichAndreas H Jacobs
Apr 10, 2009·The Oncologist·Nathan A Pennell, Thomas J Lynch
Apr 28, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Nikie J HoetjesRonald Boellaard

❮ Previous
Next ❯

Citations

Apr 25, 2014·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Bal SangheraKirit Ardeshna
May 16, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Omid S Tehrani, Anthony F Shields
Dec 24, 2019·Current Radiopharmaceuticals·Silvi TeloStefano Fanti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.