Imaging short-lived reactive oxygen species (ROS) with endogenous contrast MRI

Journal of Magnetic Resonance Imaging : JMRI
Rong-Wen TainKejia Cai

Abstract

To characterize the relaxation properties of reactive oxygen species (ROS) for the development of endogenous ROS contrast magnetic resonance imaging (MRI). ROS-producing phantoms and animal models were imaged at 9.4T MRI to obtain T1 and T2 maps. Egg white samples treated with varied concentrations of hydrogen peroxide (H2 O2 ) were used to evaluate the effect of produced ROS in T1 and T2 for up to 4 hours. pH and temperature changes due to H2 O2 treatment in egg white were also monitored. The influences from H2 O2 itself and oxygen were evaluated in bovine serum albumin (BSA) solution producing no ROS. In addition, dynamic temporal changes of T1 in H2 O2 -treated egg white samples were used to estimate ROS concentration over time and hence the detection sensitivity of relaxation-based endogenous ROS MRI. The relaxivity of ROS was compared with that of Gd-DTPA as a reference. Finally, the feasibility of in vivo ROS MRI with T1 mapping acquired using an inversion recovery sequence was demonstrated with a well-established rotenone-treated mouse model (n = 6). pH and temperature changes in treated egg white samples were insignificant (<0.1 unit and <1°C, respectively). T1 relaxation time in the H2 O2 -treated egg white was reduced...Continue Reading

References

Jan 1, 1986·Annual Review of Physiology·W A Pryor
Jul 13, 1999·Free Radical Biology & Medicine·M R GuntherW S Caughey
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David J LurieJay L Zweier
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Aug 11, 2005·Physical Review Letters·Sebastiaan Y T van de MeerakkerGerard Meijer
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell
Apr 23, 2009·Neurobiology of Disease·Jason R CannonJ Timothy Greenamyre
Jul 10, 2010·Journal of Biomedical Optics·He N XuLin Z Li
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Asha AcharyaTapas Saha
Jan 31, 2012·Cellular Signalling·Paul D RayYoshiaki Tsuji
Mar 17, 2012·Journal of the American Chemical Society·S James RatnakarA Dean Sherry
Sep 15, 2012·Journal of the American Chemical Society·Andrzej RajcaSuchada Rajca
Mar 12, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mathieu SarracanieMatthew S Rosen
Sep 3, 2013·Antioxidants & Redox Signaling·Manish MittalAsrar B Malik
Sep 21, 2013·Journal of the American Chemical Society·S James RatnakarZoltan Kovacs
Feb 18, 2014·Biochimica Et Biophysica Acta·Franz-Josef SchmittSuleyman I Allakhverdiev
Oct 1, 2014·Journal of the American Society for Mass Spectrometry·Yuetian YanMichael L Gross
Mar 10, 2015·Methods : a Companion to Methods in Enzymology·Antonio N CalabreseAlison E Ashcroft
Feb 18, 2016·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts

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Citations

Jul 20, 2018·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts
Jan 8, 2019·Journal of Magnetic Resonance Imaging : JMRI·Rong-Wen TainKejia Cai
Dec 7, 2019·AJNR. American Journal of Neuroradiology·P NicholsonT Krings
Sep 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Haiqi YeKejia Cai
Mar 24, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin J MacKinnonYen-Yu Ian Shih

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