Imaging systems level consolidation of novel associate memories: a longitudinal neuroimaging study.

NeuroImage
Jason F SmithBarry Horwitz

Abstract

Previously, a standard theory of systems level memory consolidation was developed to describe how memory recall becomes independent of the medial temporal memory system. More recently, an extended consolidation theory was proposed that predicts seven changes in regional neural activity and inter-regional functional connectivity. Using longitudinal event-related functional magnetic resonance imaging of an associate memory task, we simultaneously tested all predictions and additionally tested for consolidation-related changes in recall of associate memories at a sub-trial temporal resolution, analyzing cue, delay and target periods of each trial separately. Results consistent with the theoretical predictions were observed though two inconsistent results were also obtained. In particular, while medial temporal recall related delay period activity decreased with consolidation as predicted, visual cue activity increased for consolidated memories. Though the extended theory of memory consolidation is largely supported by our study, these results suggest that the extended theory needs further refinement and the medial temporal memory system has multiple, temporally distinct roles in associate memory recall. Neuroimaging analysis at a ...Continue Reading

References

Apr 1, 1995·Current Opinion in Neurobiology·L R Squire, P Alvarez
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Alvarez, L R Squire
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·E TulvingS Houle
Dec 1, 1996·Brain Research. Cognitive Brain Research·Y MiyashitaK Nakajima
Apr 1, 1997·Current Opinion in Neurobiology·L Nadel, M Moscovitch
Dec 5, 1998·Brain Research. Cognitive Brain Research·E ZarahnM D'Esposito
Mar 12, 1999·Science·E E Smith, J Jonides
Nov 5, 1999·NeuroImage·K J FristonA M Dale
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Jan 29, 2002·Hippocampus·J R Manns, L R Squire
Aug 9, 2002·Journal of Cognitive Neuroscience·Michael B MillerMichael S Gazzaniga
Sep 21, 2002·Science·K L Hoffman, B L McNaughton
Jan 25, 2003·Science·Michael M ZeinehSusan Y Bookheimer
Feb 5, 2003·Brain : a Journal of Neurology·Martina PiefkeGereon R Fink
Apr 15, 2003·Neuron·Joseph R MannsLarry R Squire
May 14, 2003·Behavioural Brain Research·Melissa J GlennDave G Mumby
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Mar 31, 2004·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Jun 29, 2004·NeuroImage·Pascale PiolinoFrancis Eustache
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura L EldridgeBarbara J Knowlton
Jul 15, 2005·Hippocampus·Simone BosshardtKatharina Henke
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry HorwitzTheresa W Long
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaG Fernández
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Mar 6, 2007·Current Opinion in Neurobiology·Larry R Squire, Peter J Bayley
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Oct 20, 2007·Nature Reviews. Neuroscience·Larry R SquireRobert E Clark

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Citations

Mar 27, 2012·Annual Review of Neuroscience·Yadin Dudai
Jan 8, 2016·Journal of Cognitive Neuroscience·Jesse RissmanAnthony D Wagner
Oct 9, 2015·Neuron·Yadin DudaiJan Born
May 28, 2014·NeuroImage·Raphael HilgenstockOtto W Witte
Jul 28, 2016·Neurobiology of Aging·Juraj KukoljaGereon R Fink

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