Imaging the cellular biology of the carotid plaque

International Journal of Stroke : Official Journal of the International Stroke Society
J M U-King-ImJ H Gillard

Abstract

Carotid atherosclerotic disease is a significant preventable cause of stroke. Clinical decision-making in current practice is based primarily on detection of the severity of luminal stenosis, as determined by ultrasound or conventional angiographic imaging modalities. New insights in the biology of atherosclerosis now suggests that the morphological characteristics of the carotid plaque as well as the molecular and cellular processes occurring within it may be more important markers of plaque vulnerability and stroke risk. This review summarizes emerging applications in the molecular imaging of atherosclerosis and detection of the vulnerable carotid plaque. We discuss how advances in imaging platforms and biochemical technology (e.g. targeted contrast agents) have driven some exciting and promising novel diagnostic imaging approaches from bench to bedside.

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Citations

May 19, 2009·Lancet Neurology·Jean Marie U-King-ImJonathan H Gillard
May 16, 2009·Neuroimaging Clinics of North America·Dheeraj GandhiJoseph J Gemmete
Sep 22, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Lonneke M L de LauDiederik W J Dippel
Oct 20, 2009·Journal of Vascular Surgery·Nikolaos P E KadoglouChristos D Liapis
Apr 16, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C D LiapisUNKNOWN ESVS Guidelines Collaborators

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Methods Mentioned

BETA
electron microscopy
Transmission electron microscopy
fluorescence imaging
imaging techniques

Related Concepts

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