PMID: 2115074Aug 1, 1990Paper

Imaging the dopamine uptake site with ex vivo [18F]GBR 13119 binding autoradiography in rat brain

Journal of Neurochemistry
B J CiliaxJ B Penney

Abstract

We studied the binding of [18F]GBR 13119 (1-[[(4-[18F]fluorophenyl) (phenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine) to rat brain with autoradiography after intravenous injection. The rank order of binding was dorsal striatum greater than nucleus accumbens = olfactory tubercle greater than substantia nigra = ventral tegmental area greater than other areas. Binding was blocked by prior injection of dopamine uptake blockers but not by injection of dopamine receptor antagonists or drugs that bind to the dialkylpiperazine site. Unilateral 6-hydroxy-dopamine lesions of dopamine neurons caused a marked decrease in striatal and nigral binding on the side of the lesion. We conclude that intravenous injection of [18F]GBR 13119 provides a useful marker of presynaptic dopamine uptake sites.

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Citations

Sep 1, 1995·Medicinal Research Reviews·F I CarrollM J Kuhar
Jul 1, 1994·European Journal of Nuclear Medicine·M R Kilbourn
May 27, 1992·European Journal of Pharmacology·M R KilbournT Pisani
Jan 7, 1992·European Journal of Pharmacology·J M VaugeoisJ Costentin
Oct 26, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B CarontiG Palladini
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M R KilbournT Pisani
Sep 6, 2003·The European Journal of Neuroscience·D StanicM K Horne

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