Imaging the effects of castration on bone turnover and hormone-independent prostate cancer colonization of bone.

The Prostate
N A CrossC L Eaton

Abstract

Tumor populations may selectively colonize bone that is being actively remodeled. In prostate cancer patients, androgen deprivation directly inhibits tumor growth initially, whilst induced bone loss may facilitate tumor colonization of bone by androgen-insensitive cells. We have tested this hypothesis using a xenograft model of early growth of prostate cancer in bone. PC3 cells transfected with Green fluorescent protein (GFP) were injected into castrated and non-castrated athymic mice via intrabial and intracardiac routes. In vivo tumor growth was monitored daily and animals sacrificed 6-9 days following initial GFP-based detection of tumors. Tumor bearing and contra-lateral non-tumor bearing tibias were analyzed extensively by micro-CT and histology/immunohistochemistry for the presence of tumor cells and the effects of tumor and/or castration on bone cells and bone structure evaluated. GFP-positive tumors in bone were visible from 12 days post-injection following intratibial injection, allowing tumors <1 mm diameter to be monitored in live animals. Castration did not affect tumor frequency, tumor volume, or time to initial appearance of tumors injected via intratibial or intracardiac routes. Castration decreased trabecular bo...Continue Reading

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Citations

Dec 25, 2009·Journal of Photochemistry and Photobiology. B, Biology·Frederic LeblondBrian W Pogue
Jul 1, 2009·International Journal of Experimental Pathology·Carolyn A StatonNicola J Brown
Aug 27, 2014·International Journal of Cancer. Journal International Du Cancer·Kimberley J ReevesNicola J Brown

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