Imaging the microvasculature of choroidal melanomas with confocal indocyanine green scanning laser ophthalmoscopy

Archives of Ophthalmology
A J MuellerW R Freeman

Abstract

To image the microvasculature of choroidal melanoma with a new confocal scanning laser ophthalmoscope. Eighteen consecutive patients, each with a unilateral choroidal melanoma, were examined prospectively. Indocyanine green angiography was performed with a new confocal scanning laser ophthalmoscope that enabled serial optical sectioning through the tumor. Two additional patients were studied with indocyanine green angiography and confocal scanning laser ophthalmoscopy just before enucleation for posterior choroidal melanomas. The histologic identification of microvasculature patterns was compared with the angiograms for these patients. In the series of 18 patients, 16 (89%) indocyanine green angiograms with optical sectioning revealed tubular structures within the melanoma that were identified as tumor vessels based on their angiographic appearance. The microvasculature patterns identified by indocyanine green angiography correlated well with the histologic appearance of these microvasculature patterns in both patients for whom histologic verification was available. This preliminary study suggests that indocyanine green angiography with confocal scanning laser ophthalmoscopy images the microvasculature of choroidal melanomas an...Continue Reading

Citations

Aug 26, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·David E Lederer, Chaim Edelstein
Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Feb 10, 2000·The American Journal of Pathology·D M McDonaldR K Jain
Jul 4, 2009·Retina·Kenichiro BesshoWilliam R Freeman
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Fabian KiesslingFrauke Alves
Jun 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lothar KrauseMichael H Foerster
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Robert Folberg, Andrew J Maniotis
Sep 30, 2004·Acta Ophthalmologica Scandinavica·Peter IsagerJens Overgaard
Jul 6, 2004·Magnetic Resonance Imaging·Matthias H J KrauseLucy H Y Young
Jun 6, 2006·Ophthalmology·Arun D SinghIan G Rennie
Jun 8, 2010·Journal of Experimental & Clinical Cancer Research : CR·Wei WangBaocun Sun
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi KalikiJerry A Shields
Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Jun 6, 2013·TheScientificWorldJournal·Aneesh K RamaswamyCraig J Goergen
Mar 2, 1999·Journal of the National Cancer Institute·T MäkitieT Kivelä
Jan 7, 2004·Retina·Richard F SpaideTomohiro Iida
Oct 31, 2017·Ocular Immunology and Inflammation·Ankush KawaliPadmamalini Mahendradas
Feb 7, 2009·Journal of Endourology·Geoffrey A SonnJoseph C Liao
Oct 28, 1999·Current Opinion in Ophthalmology·C D Regillo
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·M C Kincaid
Mar 15, 2020·Journal of Hematology & Oncology·Qingxi LuoChaojun Duan
May 14, 2009·Seminars in Ophthalmology·Pooja BhatRobert Folberg
Aug 3, 2020·Asia-Pacific Journal of Ophthalmology·Alessandro InvernizziJay Chabblani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.