Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ana MoragaIgnacio Lizasoain

Abstract

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

References

Aug 30, 2000·Nature·A Aderem, R J Ulevitch
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Johan AarumMats A A Persson
Dec 26, 2006·Biochemical and Biophysical Research Communications·Can-Xiang CaoJing-Zhou Wang
Apr 26, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Santiago RojasAnna M Planas
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sung-Chun TangMark P Mattson
Aug 21, 2007·Nature Cell Biology·Asya RollsMichal Schwartz
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Javier R CasoIgnacio Lizasoain
Apr 9, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael SchroeterRudolf Graf
Oct 2, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Abraham MartínBertrand Tavitian
Dec 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexandra WinkelerBertrand Tavitian
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Adele RuegerMichael Schroeter
Jul 10, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Frederick M LarteyBilly W Loo
Jul 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana MoragaIgnacio Lizasoain
Jan 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fang HuaDonald G Stein
Jul 2, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bastian ZinnhardtAndreas H Jacobs

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Citations

Oct 24, 2018·CNS Neuroscience & Therapeutics·Xin WangWei-Feng Yu
Mar 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christos TapeinosGianni Ciofani
Aug 28, 2020·Frontiers in Neuroscience·María ArdayaAbraham Martín
Feb 16, 2017·Frontiers in Neuroinformatics·Inge A MulderArn M J M van den Maagdenberg
Aug 6, 2020·Frontiers in Cellular Neuroscience·Luting YuYi Qu
Jan 4, 2017·International Journal of Molecular Sciences·Bàrbara Laviña
Jan 9, 2021·Frontiers in Neuroscience·Juan Miguel ValverdeJussi Tohka
Jul 11, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Nadja Van CampHervé Boutin

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

ImageJ
CellQuest
GraphPad Prism
PMOD

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