Imaging the urinary pathways in mice by liposomal indocyanine green

Nanomedicine : Nanotechnology, Biology, and Medicine
Emma PortnoySara Eyal

Abstract

Intraoperative ureter identification can assist in the prevention of ureteral injury and consequently improve surgery outcomes. Our aim was to take advantage of the altered pharmacokinetics of liposomal indocyanine green (ICG), the only FDA-approved near-infrared (NIR) dye, for imaging of ureters during surgeries. ICG was passively adsorbed to liposomes. NIR whole mice body and isolated tissue imaging were used to study liposomal ICG properties vs. free ICG. In vivo, the urinary bladder could be clearly observed in most of the liposome-treated mice. Liposomal encapsulation of ICG enhanced ureteral emission up to 1.9 fold compared to free ICG (P<0.01). Increase in liposomal micropolarity and microviscosity and differential scanning calorimetry supported ICG localization within the liposomal bilayer. Our findings suggest that liposomal ICG could be utilized for ureteral imaging intra-operatively, thus potentially improving surgical outcomes. Iatrogenic ureteral injury is a serious complication of abdominal surgery and intra-operative recognition of the ureters is usually the best method of injury prevention. In this article, the authors developed liposomal indocyanine green, which could be excreted via the urinary system and inve...Continue Reading

References

Mar 1, 1990·Chemistry and Physics of Lipids·M C Pedroso de LimaN Düzgüneş
Sep 1, 1993·Archives of Ophthalmology·S Yoneya, K Noyori
Mar 1, 1996·The Journal of Urology·A A Selzman, J P Spirnak
Apr 11, 2000·Seminars in Surgical Oncology·S W Larach, J T Gallagher
May 12, 2001·Burns : Journal of the International Society for Burn Injuries·J M StillJ Z Holtz
Dec 26, 2001·Chemical Reviews·A MishraG B Behera
Apr 1, 1960·The Journal of Clinical Investigation·G R CHERRICKC S DAVIDSON
Sep 23, 2003·Journal of Pharmaceutical Sciences·Vishal SaxenaJun Shao
Dec 31, 2004·Optometry : Journal of the American Optometric Association·Victoria L DzurinkoJason R Price
Feb 24, 2005·International Journal of Pharmaceutics·G M M El MaghrabyB W Barry
Apr 15, 2005·Biophysical Chemistry·Valeriya Ioffe, Galyna P Gorbenko
May 20, 2005·American Journal of Obstetrics and Gynecology·Babak VakiliThomas E Nolan
Jun 25, 2005·Hospital Medicine·Olanrewaju Sorinola, Roksana Begum
Dec 1, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Ja-Hong KimSandip Vasavada
Jan 3, 2006·International Journal of Pharmaceutics·Vishal SaxenaJun Shao
Sep 18, 2007·The Journal of Urology·Eiichi TanakaJohn V Frangioni
Jan 1, 2008·Journal of Biomedical Optics·Mohammad A YaseenBahman Anvari
Jan 24, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·Mou-Tsy ChouRay-Chang Lien
Sep 9, 2010·Cancer Research·Steven T ProulxMichael Detmar
Jan 29, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Emma PortnoyShlomo Magdassi
Jul 5, 2011·Biomaterials·Shenglin LuoChunmeng Shi
Mar 2, 2012·Korean journal of urology·Jeong Hyun ParkMoon Ki Jo
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
Sep 24, 2014·Central European Journal of Urology·Wojciech PolomMarcin Matuszewski

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Citations

Mar 5, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Pradeep TyagiNaoki Yoshimura
Feb 6, 2017·Surgical Innovation·Shlomo MagdassiEran Nizri
Jul 2, 2019·Current Opinion in Obstetrics & Gynecology·Gaby MoawadMichelle Louie
Jan 11, 2019·Pharmaceutics·Catarina Oliveira SilvaCatarina Reis
Nov 12, 2019·Frontiers in Pharmacology·Vijay Sagar MadamsettySudip Mukherjee
Sep 2, 2020·Biomaterials·Anila Hoskere AshokaAndrey S Klymchenko

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