Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT.

Biomedical Optics Express
Heike H MüllerGereon Hüttmann

Abstract

Visualizing retinal photocoagulation by real-time OCT measurements may considerably improve the understanding of thermally induced tissue changes and might enable a better reproducibility of the ocular laser treatment. High speed Doppler OCT with 860 frames per second imaged tissue changes in the fundus of enucleated porcine eyes during laser irradiation. Tissue motion, measured by Doppler OCT with nanometer resolution, was correlated with the temperature increase, which was measured non-invasively by optoacoustics. In enucleated eyes, the increase of the OCT signal near the retinal pigment epithelium (RPE) corresponded well to the macroscopically visible whitening of the tissue. At low irradiance, Doppler OCT revealed additionally a reversible thermal expansion of the retina. At higher irradiance additional movement due to irreversible tissue changes was observed. Measurements of the tissue expansion were also possible in vivo in a rabbit with submicrometer resolution when global tissue motion was compensated. Doppler OCT may be used for spatially resolved measurements of retinal temperature increases and thermally induced tissue changes. It can play an important role in understanding the mechanisms of photocoagulation and, ev...Continue Reading

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Citations

Feb 7, 2015·Biomedical Optics Express·Kazuhiro KurokawaYoshiaki Yasuno
May 31, 2013·Acta Ophthalmologica·Stefan KoinzerJohann Roider
Apr 5, 2014·Clinical & Experimental Ophthalmology·Young-Gun ParkRalf Brinkmann
Oct 20, 2012·Biomedical Optics Express·Kazuhiro SasakiYoshiaki Yasuno
Apr 25, 2015·Biomedical Optics Express·Kathy BeaudetteCaroline Boudoux
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dierck HillmannGereon Hüttmann
Oct 21, 2016·Scientific Reports·Dierck HillmannGereon Hüttmann
May 12, 2017·Journal of Biophotonics·Vladimir Y ZaitsevEmil N Sobol
Feb 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Georges GoetzDaniel Palanker
Mar 16, 2019·Optics Letters·Hendrik SpahrDierck Hillmann
Mar 30, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yoko MiuraRalf Brinkmann
Jul 9, 2020·Biomedical Optics Express·Raphaël Maltais-TariantNéstor Uribe-Patarroyo
Dec 15, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Amy Dagro, Justin Wilkerson
Aug 24, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Amy M DagroJames D Hogan

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Methods Mentioned

BETA
irradiating
Fluorescence

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