Imatinib and everolimus in patients with progressing advanced chordoma: A phase 2 clinical study

Cancer
Silvia StacchiottiPaolo G Casali

Abstract

We present the results of an academic phase 2 study on imatinib plus everolimus in patients who have progressive advanced chordoma. In January 2011, 43 adult chordoma patients were enrolled in the study and received imatinib 400 mg/day and everolimus 2.5 mg/day until progression or limiting toxicity. Eligible patients had progressed in the 6 months before study entry. PDGFRB, S6, and 4EBP1 expression and phosphorylation were evaluated by way of immunohistochemistry and/or western blotting. The primary endpoint was the overall response rate (ORR) according to Choi criteria. Secondary endpoints were RECIST 1.1 response, progression-free survival (PFS), overall survival (OS), correlation between S6/4EBP1 phosphorylation and response. Thirteen of 43 patients were pretreated with imatinib. Among 40 of the 43 patients who were evaluable by Choi criteria, the best responses were 9 with partial response (ORR, 20.9%), 24 with stable disease (SD) (ORR, 55.8%), and 7 with progressive disease (ORR, 16.3%). Forty-two patients were evaluable by RECIST criteria, with 1 partial response (ORR, 2.3%), 37 stable disease (ORR, 86%), and 4 progressive disease (ORR, 9.3%). The median PFS according to Choi criteria was 11.5 months (range, 4.6-17.6 mo...Continue Reading

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Citations

Dec 27, 2018·Current Opinion in Oncology·Anna Maria FrezzaSilvia Stacchiotti
Feb 27, 2020·Der Pathologe·Susanne ScheiplBernadette Liegl
Jul 7, 2019·Journal of Hematology & Oncology·Hui HuaYangfu Jiang
Aug 1, 2020·Frontiers in Neurology·Samantha E HoffmanWenya Linda Bi
Aug 14, 2020·Journal of Neuro-oncology·J D PalmerD M Trifiletti
Dec 22, 2020·Laryngo- rhino- otologie·Frank Haubner, Walter Rachinger
Feb 17, 2021·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba
Apr 25, 2021·Targeted Oncology·Oluwaseun O AkinduroAlfredo Quiñones-Hinojosa
May 14, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S RadaelliA Gronchi
Jun 5, 2021·European Journal of Pharmacology·Meng-Chao XiaoWei-Fen Xie
Jul 17, 2021·Current Problems in Cancer·Mary Frances WedekindGregory Cote
Jun 17, 2020·Neuroendocrinology·Natalia KremenevskiMichael Buchfelder

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