Imatinib for progressive and recurrent aggressive fibromatosis (desmoid tumors): an FNCLCC/French Sarcoma Group phase II trial with a long-term follow-up

Annals of Oncology : Official Journal of the European Society for Medical Oncology
N PenelJ-Y Blay

Abstract

Imatinib evaluated as a new treatment option in patients with recurrent or established progressive aggressive fibromatosis/desmoid tumor (AF/DT). Forty patients with unresectable and progressive symptomatic AF/DT were treated with imatinib (400 mg/day for 1 year) in a Simon's optimal two-stage phase II study (P(0) = 10%, P(1) = 30%, α = 5%, β = 10%). The primary end point was non-progressive at 3 months (RECIST). The study population consisted of 28 women and 12 men, with a mean age of 41 (range 20-72 years). Most of the primary sites were extra-abdominal (24, 54.5%). Familial adenomatous polyposis was observed in six (15%) cases. The median follow-up was 34 months. Imatinib toxicity was similar to that previously reported in literature. Tumor assessment was validated by a central independent radiology committee for 35 patients At 3 months, one (3%) complete and three (9%) partial confirmed responses were observed. The non-progression rates at 3, 6 and 12 months were, respectively, 91%, 80% and 67%. The 2-year progression-free and overall survival rates were 55% and 95%, respectively. Two patients with mesenteric AF/DT died from progressive disease. Imatinib is active in the treatment of recurrent and progressive AF/DT, providi...Continue Reading

References

Mar 1, 1989·Controlled Clinical Trials·R Simon
Feb 1, 1989·Archives of Surgery·M C PosnerM F Brennan
Aug 1, 1996·Controlled Clinical Trials·M Schemper, T L Smith
Jun 12, 2002·Current Treatment Options in Oncology·J S Biermann
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Robert G MakiCristina R Antonescu
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GronchiJ Rosai
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Oliver MickeUNKNOWN German Cooperative Group on Radiotherapy for Benign Diseases
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard Simon
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Makoto GegaTakehira Yamamura
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Dec 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen X SkapekUNKNOWN Pediatric Oncology Group
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dina LevRaphael E Pollock
Aug 22, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S BonvalotC Le Péchoux
Feb 26, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-Y BlayI Ray-Coquard
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael C HeinrichUNKNOWN Imatinib Target Exploration Consortium Study B2225
Jun 4, 2008·Sarcoma·G MitchellC L Harmer
Jun 21, 2008·The New England Journal of Medicine·Nicolas PenelAntoine Adenis

❮ Previous
Next ❯

Citations

Jun 19, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Bernd KasperPeter Hohenberger
Apr 4, 2009·Targeted Oncology·Florence Duffaud, Axel Le Cesne
Mar 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GarbayA Italiano
Aug 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C EscobarG V Burton
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BonvalotA Le Cesne
Sep 12, 2012·Sarcoma·A P MolloyG C O'Toole
Jun 16, 2012·Sarcoma·George T CalvertR Lor Randall
Jan 23, 2009·World Journal of Surgical Oncology·Chee Khoon LeeDavid Goldstein
Apr 12, 2011·The Oncologist·Bernd KasperPeter Hohenberger
Jun 13, 2012·Journal of Radiology Case Reports·Michael J Plaza, Monica Yepes
Apr 21, 2012·Future Oncology·Marc DebledAntoine Italiano
Dec 12, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GronchiUNKNOWN ISG and FSG
Jun 26, 2014·Chemotherapy Research and Practice·Nida Iqbal, Naveed Iqbal
Aug 21, 2014·International Journal of Colorectal Disease·Poras Chaudhary
May 23, 2012·Current Treatment Options in Oncology·Ann W Silk, Scott M Schuetze
Oct 17, 2015·Expert Review of Anticancer Therapy·Mushriq Al-JazraweBenjamin Alman
Mar 12, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N EastleyR Ashford
Jan 21, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Weiqi WangDelin Lei
Oct 8, 2013·Hematology/oncology Clinics of North America·Sumana Devata, Rashmi Chugh
Aug 29, 2013·Journal of the American Academy of Dermatology·Courtney J EnsslinMario E Lacouture
Jul 3, 2013·Medicina clínica·Luis Vida Pérez, Francisca Martínez Rivas
May 31, 2013·Current Problems in Cancer·Sujana Movva
Jan 1, 2014·Pathology·Cyril Fisher, Khin Thway
Apr 23, 2015·International Journal of Clinical Oncology·Yoshihiro NishidaNaoki Ishiguro
Aug 22, 2012·Head & Neck·Mathijs P HendriksCarla M L van Herpen
Jan 15, 2014·Head & Neck·Eelco de BreeRemco de Bree
Feb 25, 2015·Cancer Science·Armelle DufresneJean-Yves Blay
Jun 6, 2015·Annals of Surgical Oncology·Danique L M van BroekhovenCornelis Verhoef
Jun 10, 2015·Molecular and Cellular Therapies·Maria Vittoria EnzoDaniela Segat
Nov 26, 2014·BMC Cancer·Lauriane EberstIsabelle Ray-Coquard
Dec 2, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B KasperUNKNOWN Desmoid Working Group
Oct 16, 2014·Familial Cancer·Thibault DesurmontYann Parc
Jun 2, 2016·Case Reports in Surgery·Jaqueline MajorsJeremiah L Deneve
Nov 28, 2013·Clinical Sarcoma Research·Juan Martin-LiberalIan Judson
Jun 12, 2016·Journal of Medical Case Reports·Hidetaka MiyashitaHiromasa Kawana
Sep 4, 2016·Surgical Oncology Clinics of North America·Marco FioreChiara Colombo
Aug 10, 2016·Skeletal Radiology·Pooja J ShethTy K Subhawong
Aug 21, 2016·The Surgical Clinics of North America·Valerie P GrignolJohn Harrison Howard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S BonvalotC Le Péchoux
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
E StoeckleB Nguyen Bui
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Michael C HeinrichJonathan A Fletcher
Annals of Oncology : Official Journal of the European Society for Medical Oncology
J JaninisJ S Whelan
© 2021 Meta ULC. All rights reserved