Imatinib Increases Serum Creatinine by Inhibiting Its Tubular Secretion in a Reversible Fashion in Chronic Myeloid Leukemia

Clinical Lymphoma, Myeloma & Leukemia
Emmanuelle Vidal-PetiotMartin Flamant

Abstract

Monitoring renal function is important in imatinib-treated patients with chronic myeloid leukemia because serum creatinine may increase during the course of therapy. The mechanism of this increase and its reversibility on treatment cessation have never been investigated. We retrospectively analyzed data from imatinib-treated patients explored in our renal physiology unit with measurement of glomerular filtration rate (urinary clearance of (51)CrEDTA) and of urinary clearance and tubular secretion of creatinine. Results were compared with those of controls matched for measured glomerular filtration rate, age, gender, and ethnicity. We also analyzed variations of serum creatinine before and during imatinib cessation and after imatinib resumption in patients enrolled in imatinib discontinuation studies. In 4 imatinib-treated patients who underwent thorough renal exploration, the part of creatinine clearance due to tubular secretion was negligible (2.4, 3.1, -1.3, and 2.8 mL/min) and significantly lower than that measured in their respective controls (17.7 ± 5.6, 43.0 ± 18.0, 23.1 ± 6.7, and 18.6 ± 5.6 mL/min, P < .001). In 1 patient, exploration was repeated after imatinib discontinuation and evidenced a recovery of creatinine tub...Continue Reading

References

Jul 1, 1990·Kidney International·A S Levey
Nov 1, 1985·Kidney International·O ShemeshB D Myers
Apr 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W N DeiningerBrian J Druker
Jun 24, 2004·Pharmaceutical Research·Yumiko UrakamiKen-ichi Inui
Jan 22, 2005·Journal of the American Society of Nephrology : JASN·Marc FroissartPascal Houillier
Dec 8, 2006·The New England Journal of Medicine·Brian J DrukerUNKNOWN IRIS Investigators
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jan 8, 2010·American Journal of Physiology. Renal Physiology·Henriette E Meyer zu SchwabedissenRichard B Kim
Feb 12, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M S MarcolinoA L Ribeiro
Mar 23, 2011·Journal of the National Cancer Institute·Carlo Gambacorti-PasseriniDong-Wook Kim
Feb 26, 2013·The AAPS Journal·Hideyuki Motohashi, Ken-ichi Inui

❮ Previous
Next ❯

Citations

Jul 13, 2016·Advances in Anatomic Pathology·Megan L TroxellNeeraja Kambham
Mar 25, 2017·Journal of Pharmaceutical Sciences·Hiroshi ArakawaIkumi Tamai
Jan 8, 2019·Open Medicine·Umit Y Malkan, Ibrahim C Haznedaroglu
Aug 26, 2017·Journal of the American Society of Nephrology : JASN·Vladimir TesarAndreas Serra
Nov 25, 2019·Current Hematologic Malignancy Reports·Florence RabianDelphine Rea
Aug 30, 2017·Expert Opinion on Drug Metabolism & Toxicology·Eve-Irene Lepist, Adrian S Ray
Jun 20, 2018·Scientific Reports·Saki OmoteIkumi Tamai
Apr 10, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Terry King-Wing MaFrederick Wai Keung Tam
Dec 28, 2018·Journal of Hematology & Oncology·Jorge E CortesCarlo Gambacorti-Passerini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.