Imatinib-induced irreversible interstitial lung disease: A case report.

Medicine
Ping ZhangGuifang Ouyang

Abstract

Imatinib mesylate (imatinib) is a classic tyrosine kinase inhibitor used to treat chronic myeloid leukemia. Although it is well tolerated by most patients and helps in the achievement of complete remission, a few rare imatinib-associated adverse effects such as pulmonary interstitial fibrosis have been reported. Because of its rareity, the clinical features of imatinib-induced interstitial lung disease (ILD) remain unclear. A 49-year-old Chinese man with chronic myeloid leukemia received oral treatment with imatinib and initially exhibited a good response. However, he presented with cough and fever 9 months after treatment initiation. Pulmonary computed tomography indicated diffuse interstitial fibrosis in both lungs. All tests for possible infectious pathologies provided negative results. The patient was diagnosed with interstitial pneumonia and treated with antibiotics; however, there was no improvement. On the basis of a suspicion of imatinib-induced ILD, imatinib was discontinued and prednisone treatment was initiated. The patient's symptoms ameliorated with treatment, and imatinib was reintroduced. However, he developed cough and dyspnea again, and his treatment was switched to nilotinib as a second-line regimen. He was re...Continue Reading

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Apr 10, 2008·Leukemia & Lymphoma·Oliver HantschelGiulio Superti-Furga
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Citations

Jun 13, 2020·The European Respiratory Journal·Jason WeatheraldDavid Montani
Dec 31, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Faten KallelMoez Elloumi
Jun 8, 2021·Clinical Case Reports·Qiuying Selina LiuCecilia Arana Yi

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