PMID: 15239392Jul 9, 2004Paper

Imatinib mesylate in combination with other chemotherapeutic agents for chronic myelogenous leukemia

International Journal of Hematology
Tetsuzo Tauchi, Kazuma Ohyashiki

Abstract

Imatinib therapy is an important contribution to the management of patients with chronic myelogenous leukemia (CML). Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of CML. Experimental and clinical studies suggest that imatinib as a single drug may not be sufficient to eradicate BCR-ABL-positive stem cells. Therefore, whether combinations of imatinib with other agents can increase the length of molecular remission and whether such combinations can prolong survival should be determined by large-scale clinical studies. In this review, we discuss efficacious combinations for future clinical trials. These regimens combine imatinib with conventional chemotherapeutic agents or with inhibitors of other signal transduction molecules that may be preferentially activated in CML cells.

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Citations

Jul 31, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ingo Roeder, Ingmar Glauche
Feb 12, 2013·Experimental Hematology·Tomasz StoklosaPawel Wlodarski
Jun 22, 2005·Journal of Theoretical Biology·Rob DeCondePeter P Lee

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