PMID: 15239390Jul 9, 2004Paper

Imatinib mesylate in the treatment of chronic myelogenous leukemia

International Journal of Hematology
Gautam Borthakur, Jorge Cortes

Abstract

Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogenetic response with imatinib, molecular monitoring of disease has become mandatory in assessing response and determining prognosis. The practical aspects of the treatment of CML with imatinib are discussed. The emergence of imatinib resistance, albeit in a small percentage of patients, has prompted an evaluation of innovative treatment strategies.

References

Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Mar 1, 2002·The New England Journal of Medicine·Hagop KantarjianUNKNOWN International STI571 CML Study Group
Nov 1, 2002·Current Opinion in Oncology·Ramadevi Nimmanapalli, Kapil Bhalla
Mar 15, 2003·The New England Journal of Medicine·Stephen G O'BrienUNKNOWN IRIS Investigators
Apr 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W N DeiningerBrian J Druker
Sep 13, 2003·Leukemia·E OlavarriaUNKNOWN Chronic Leukaemia Working Party of the European Group of Bone and Marrow Transplantation (EBMT)
Oct 10, 2003·The New England Journal of Medicine·Tim P HughesUNKNOWN International Randomised Study of Interferon versus STI571 (IRIS) Study Group

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Citations

Jul 31, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ingo Roeder, Ingmar Glauche
Oct 9, 2009·Current Opinion in Pediatrics·Thomas P Slavin, Georgia L Wiesner
May 5, 2009·Blood Cells, Molecules & Diseases·Ingo RoederUNKNOWN other participants
Sep 24, 2014·Drug Discovery Today·Djoeke de WitNielka P van Erp
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou

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