Imatinib plasma trough concentration and its correlation with characteristics and response in Chinese CML patients.

Acta Pharmacologica Sinica
Qiu-bai LiPing Zou

Abstract

To investigate the pharmacokinetics of imatinib in Chinese chronic myelogenous leukemia (CML) patients. Fourty-six naïve Chinese CML patients treated with imatinib (400 and 600 mg daily, n=36 and 10, respectively) were recruited. The correlations of imatinib (400 mg) trough plasma concentrations (C(mins)) with the patients' characteristics and responses were analyzed. The overall mean (+/-SD, CV%) steady-state C(mins) for imatinib at 400 mg (n=36) and 600 mg (n=10) daily was 1325.61 ng/mL (+/-583.53 ng/mL; 44%) and 1550.90 ng/mL (+/-462.63 ng/mL; 30%), respectively, and no statistically significant differences were found between them (P=0.267). At 400 mg daily, female patients had significantly higher C(mins) than the male patients (P=0.048), and molecular responses were not correlated with imatinib C(mins), but they were correlated with time elapsed before imatinib therapy. The results suggest that Chinese CML patients have higher imatinib C(mins) than their Caucasian counterparts and that the optimal initial imatinib dose for them requires further investigation.

References

Mar 15, 2003·The New England Journal of Medicine·Stephen G O'BrienUNKNOWN IRIS Investigators
Aug 19, 2003·Leukemia Research·Akira HorikoshiShigemasa Sawada
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bin PengRenaud Capdeville
Jul 24, 2004·Hematology/oncology Clinics of North America·Junia V Melo, Michael W N Deininger
Jun 21, 2005·British Journal of Clinical Pharmacology·H SchmidliUNKNOWN IRIS Study Group
Jul 12, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hans-Peter GschwindGerhard Gross
Jul 22, 2005·Blood·Lucy C CrossmanRichard E Clark
Aug 27, 2005·Clinical Pharmacokinetics·Bin PengHorst Schran
Dec 8, 2006·The New England Journal of Medicine·Brian J DrukerUNKNOWN IRIS Investigators
Nov 3, 2007·The Lancet Oncology·Jane F Apperley
Feb 8, 2008·Blood·Richard A LarsonUNKNOWN IRIS (International Randomized Interferon vs STI571) Study Group
Jul 26, 2008·Cancer Letters·Gisella VolpeDaniela Cilloni
Aug 16, 2008·Annals of Hematology·Shinichi KobayashiKazuo Motoyoshi

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Citations

Jan 7, 2016·Drug Metabolism and Pharmacokinetics·Masatomo Miura, Naoto Takahashi
Jan 13, 2018·Clinical Pharmacology and Therapeutics·Gaurav BajajJennifer Sheng
Sep 21, 2013·Therapeutic Drug Monitoring·Debra H JosephsRobert J Flanagan
Oct 28, 2017·Expert Review of Clinical Pharmacology·Meinolf SuttorpEberhard Schleyer
Sep 19, 2021·British Journal of Clinical Pharmacology·Jeffry AdiwidjajaAndrew J McLachlan

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