Imatinib treatments have long-term impact on placentation and embryo survival

Scientific Reports
Wael SalemLynda K McGinnis

Abstract

Imatinib is an oral chemotherapeutic used primarily to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). The potential effects of cancer treatments on a patient's future fertility  are a major concern affecting the quality of life for cancer survivors. The effects of imatinib on future fertility are unknown. It is teratogenic. Therefore, patients are advised to stop treatment before pregnancy. Unfortunately, CML and GIST have high rates of recurrence in the absence of the drug, therefore halting imatinib during pregnancy endangers the mother. Possible long-term (post-treatment) effects of imatinib on reproduction have not been studied. We have used a mouse model to examine the effects of imatinib on the placenta and implantation after long-term imatinib exposure. We found significant changes in epigenetic markers of key imprinted genes in the placenta. There was a significant decrease in the labyrinth zone and vasculature of the placenta, which could impact fetal growth later in pregnancy. These effects on placental growth occurred even when imatinib was stopped prior to pregnancy. These results indicate potential long-term effects of imatinib on pregnancy and implantation. A prolonged wash-out pe...Continue Reading

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Citations

May 7, 2020·Journal of Assisted Reproduction and Genetics·Wael SalemLynda K McGinnis
Sep 30, 2020·Human & Experimental Toxicology·Z Topal SuzanH A Uydu
Oct 7, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Michael W DeiningerHema Sundar
Apr 8, 2021·Journal of Assisted Reproduction and Genetics·Anupama RambhatlaMili Thakur
Jun 5, 2021·Journal of Human Reproductive Sciences·Manish BankerSandeep Shah
Jun 10, 2021·Biology of Reproduction·Kailiang LiRomana A Nowak
Jun 22, 2021·Placenta·Vera E R A WoltersFrédéric Amant
Nov 7, 2021·Developmental Cell·Niraimathi GovindasamyIvan Bedzhov
Dec 23, 2021·Journal of Natural Products·Kailiang LiJoanna E Burdette

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Methods Mentioned

BETA
methylation aberrations
dissection
PCR

Software Mentioned

GraphPad Prism
STATA
LUMA
FIJI
NDP

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