Imbalance between neutral endopeptidase 24.11 and endothelin-1 expression in human endometrial carcinoma

Oncology
T SuzukiS Mizutani

Abstract

Neutral endopeptidase 24.11 (NEP)/CD10 is a cell-surface peptidase that degrades various bioactive peptides including endothelin-1 (ET-1). This enzyme is known to play a role in maintaining ET-1-regulated vascular homeostasis in the normal human endometrium. The purpose of the present study was to investigate the expression and localization of NEP and ET-1 in neoplastic endometria, and also to clarify the correlation of their expression with the tumor grade of endometrial carcinoma. Immunohistochemical analysis for NEP and ET-1 expression was performed on paraffin-embedded tissue sections of 7 normal endometria (after menopause), 5 atypical endometrial hyperplasias (AEH), and 32 endometrial endometrioid adenocarcinomas. In normal endometrium and AEH, NEP immunoreactivity was detected in stromal cells, but not in glandular cells. In contrast, ET-1 immunoreactivity was detected in both glandular and stromal cells. In the stromal cells of grade 1 endometrial adenocarcinoma, NEP was detected at high or moderate quantities. However, significantly decreased NEP immunoreactivity was observed in the stromal cells of grade 2 and 3 adenocarcinomas. However, NEP was not immunostained in adenocarcinoma cells except for the lesions of squam...Continue Reading

Citations

Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ei Ei KhinShigehiko Mizutani
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Esther OlivaRobert H Young
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·P D'Orléans-JusteJ Labonté
Mar 3, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kiyosumi ShibataShigehiko Mizutani
Sep 29, 2004·Biological Chemistry·Kazuhiko InoShigehiko Mizutani
Sep 2, 2008·Expert Review of Anticancer Therapy·Martin Smollich, Pia Wülfing
Oct 11, 2003·Biochemical and Biophysical Research Communications·Iara GomesMartin Albrecht
Mar 14, 2003·American Journal of Obstetrics and Gynecology·Ei Ei KhinShigehiko Mizutani
Oct 6, 2014·Journal of the Egyptian National Cancer Institute·Ahmed R H Ahmed, Eman M S Muhammad
Mar 30, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takayasu SuganumaShigehiko Mizutani
Apr 14, 2010·Inhalation Toxicology·Simon S WongJefferey L Burgess
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki KajiyamaFumitaka Kikkawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.