Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Mario GalganiMarialuisa Bocchino

Abstract

Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multi-parametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p<0.001 and p<0.003) along with a marked increase of the mDC/pDC ratio (p<0.001). Analysis of peripheral lymphocyte subsets showed that the naive/memory T cell ratio was significantly reduced in COPD patients in comparison with never smokers (p<0.001). Similar perturbations in the distribution of DCs and T cells also occurred in control smokers. This study is the first report of an imbalance of blood DCs in COPD. Influence of smoking and clinical relevance of these findings are discussed.

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Citations

May 15, 2012·American Journal of Respiratory and Critical Care Medicine·Rosa FanerAlvar Agustí
Jan 23, 2016·Transplantation Research·Antonino CastellanetaAlfredo Di Leo
Jul 30, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Helena Solleiro-VillavicencioMaría Inés Vargas-Rojas
Apr 3, 2012·Journal of Clinical Laboratory Analysis·Cheng ChenJian-An Huang
Mar 17, 2015·Respiratory Research·Paul StollMarek Lommatzsch
Oct 18, 2014·The European Respiratory Journal·William MacNeeGourab Choudhury
Mar 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tine DemoorGuy F Joos
Aug 20, 2019·Respiratory Medicine·Ankit P Laddha, Yogesh A Kulkarni
May 18, 2021·Frontiers in Immunology·Marialuisa BocchinoDomenico Galati

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