Imbalance of dendritic cell co-stimulation in COPD

Respiratory Research
P StollMarek Lommatzsch

Abstract

Dendritic cells (DCs) control immunity and play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the expression of function-associated surface molecules on circulating DCs in COPD is unknown. Four-colour flow cytometry was used to compare blood DC surface molecules of 54 patients with COPD (median age: 59 years; median FEV1: 38% predicted, median CAT score: 24) with two age-matched control groups with normal lung function: 21 current smokers and 21 never-smokers. Concentrations of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) and the mDC/pDC ratio did not differ between the groups. The increased expression of BDCA-1, BDCA-3, CD86 and CCR5 on mDCs in patients with COPD did not significantly differ from smokers with normal lung function. In contrast, COPD was specifically characterised by a decreased expression of the anti-inflammatory co-stimulatory molecule PD-L1 on pDCs and an increased expression of the pro-inflammatory co-stimulatory molecule OX40 ligand (OX40L) on mDCs. These changes were not confined to patients with elevated systemic inflammation markers (leukocytes, c-reactive protein, interleukin-6, fibrinogen). The ratio of OX40L to PD-L1 expression (OX40L/PD-L1 ratio), a quantitati...Continue Reading

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Citations

Oct 28, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P StollM Lommatzsch
Sep 2, 2016·American Journal of Respiratory and Critical Care Medicine·Paul StollMarek Lommatzsch
Sep 2, 2016·American Journal of Respiratory and Critical Care Medicine·Karl J Staples, Tom M A Wilkinson
Oct 4, 2016·Respiratory Medicine·Marek LommatzschJ Christian Virchow
Apr 9, 2016·PloS One·Elena Arellano-OrdenJosé Luis López-Campos
Aug 30, 2018·The New England Journal of Medicine·Patrick M FordeDrew M Pardoll
Jul 1, 2020·Carcinogenesis·Sreekanth Chanickal NarayanapillaiFekadu Kassie
Apr 20, 2018·Journal of Immunology Research·Theodore S KapellosJoachim L Schultze
Sep 5, 2018·The New England Journal of Medicine·Marek LommatzschPaul Stoll
Mar 25, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Felix RitzmannChristoph Beisswenger
Jun 1, 2021·The Annals of Otology, Rhinology, and Laryngology·Kathryn MarcusMichael Puricelli
Jan 9, 2020·Respiration; International Review of Thoracic Diseases·Georgia MitropoulouRomain Lazor

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

SPSS
SPSS Statistics

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