Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis

Arthritis Research & Therapy
Jochen ZwerinaGeorg Schett

Abstract

Chronic arthritis typically leads to loss of periarticular bone, which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of osteoclastogenesis and bone resorption in arthritis. Bone resorption cannot be observed isolated, however, since it is closely linked to bone formation and altered bone formation may also affect inflammatory bone loss. To simultaneously assess bone resorption and bone formation in inflammatory arthritis, we developed a histological technique that allows visualization of osteoblast function by in-situ hybridization for osteocalcin and osteoclast function by histochemistry for tartrate-resistant acid phosphatase. Paw sections from human tumor necrosis factor transgenic mice, which develop an erosive arthritis, were analyzed at three different skeletal sites: subchondral bone erosions, adjacent cortical bone channels, and endosteal regions distant from bone erosions. In subchondral bone erosions, osteoclasts were far more common than osteoblasts. In contrast, cortical bone channels underneath subchondral bone erosions showed an accumulation of osteoclasts but also of functional osteoblasts resembling a status of high bone turnover. In contrast, more ...Continue Reading

References

Nov 5, 1999·Biochemical and Biophysical Research Communications·N J HorwoodM T Gillespie
Feb 29, 2000·Arthritis and Rheumatism·E M GravalleseS R Goldring
Nov 18, 2000·Arthritis and Rheumatism·Y ShigeyamaS Gay
Nov 7, 2001·The American Journal of Pathology·A R PettitE M Gravallese
May 16, 2002·Current Rheumatology Reports·Steven R Goldring, Ellen M Gravallese
Oct 9, 2002·The American Journal of Pathology·Evan RomasMatthew T Gillespie
Nov 20, 2002·The Journal of Clinical Investigation·Kurt RedlichGeorg Schett
Jul 9, 2003·Arthritis and Rheumatism·Georg SchettJosef S Smolen
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alison R Hayman, Timothy M Cox
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Birgit GörtzGeorg Schett
Dec 31, 2004·American Journal of Physiology. Endocrinology and Metabolism·Linda C GilbertMark S Nanes
Feb 8, 2005·Trends in Molecular Medicine·T John Martin, Natalie A Sims
Oct 4, 2005·Arthritis and Rheumatism·Georg SchettDebra J Zack

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Citations

Aug 24, 2013·BioMed Research International·Syed Uzair A ShahShabana U Simjee
Apr 19, 2017·Clinical and Experimental Immunology·C WehmeyerA J Naylor
Oct 31, 2009·Arthritis and Rheumatism·Camilla I SvenssonGary S Firestein
Sep 27, 2008·Current Rheumatology Reports·Heiner Appel, Joachim Sieper
Mar 3, 2010·Immunological Reviews·Nicole C Walsh, Ellen M Gravallese
Apr 8, 2015·Development, Growth & Differentiation·Caixia LiJieruo Gu
Aug 7, 2013·Arthritis and Rheumatism·Cecilia EngdahlMarie K Lagerquist
Dec 6, 2011·Arthritis and Rheumatism·Melissa M MatzelleEllen M Gravallese
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Jul 19, 2013·Clinical & Developmental Immunology·Addolorata CorradoFrancesco Paolo Cantatore

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Methods Mentioned

BETA
transgenic
acetylation

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