PMID: 3759263Oct 15, 1986Paper

Imbalance of sex chromosomes, with gain of early-replicating X, in human solid tumors

International Journal of Cancer. Journal International Du Cancer
B DutrillauxM G Seureau

Abstract

An imbalance of sex chromosomes was observed in several cases of solid tumors: colorectal, anal canal and breast carcinomas. Replication studies, using BUdR incorporation, show that in males there is a tendency towards a gain of early-replicating X and a deficiency of Y chromosomes. In females, there is a tendency towards a gain of early-replicating X and a loss of late-replicating X chromosomes. Although almost no replication studies have been published in the literature, making it impossible to distinguish between late- and early-replicating Xs, it is likely that a similar situation exists for several solid tumors other than those we have studied. A possible consequence of this imbalance is briefly discussed.

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Citations

Aug 26, 1998·Genes, Chromosomes & Cancer·M R TeixeiraS Heim
Jun 22, 2000·Genes, Chromosomes & Cancer·H L McDonaldC J Brown
Aug 1, 1995·Genes, Chromosomes & Cancer·M L LoupartJ Varley
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Jun 1, 1990·Cancer Genetics and Cytogenetics·N WangJ Dry
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Jun 9, 2010·The Journal of Pathology·José María SayaguésLuís Muñoz-Bellvis
Oct 3, 2006·Cancer Genetics and Cytogenetics·Hiroto KanekoYasuo Ohkawara

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