Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy

Journal of Clinical & Experimental Ophthalmology
Riyaz Mohamed, Azza B El-Remessy

Abstract

Diabetic retinopathy is the leading cause of blindness in working age in US and worldwide. Neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) are known to be essential for growth, differentiation and survival of neurons in the developing and mature retina. Nevertheless, a growing body of evidence supports an emerging role of neurotrophins in retinal diseases and in particular, diabetic retinopathy. Neurotrophins are initially synthesized in a pro-form and undergo proteolytic cleavage to produce the mature form that activates two distinctive receptors, the tyrosine kinase tropomycin receptor (Trk) and, to lesser extent, the common low affinity p75 neurotrophin receptor (p75(NTR)). Despite tight glycemic and metabolic control, many diabetic patients continue to experience progressive retinal damage. Understanding the molecular events involved in diabetic retinopathy is extremely important to identify novel therapeutic strategies to halt the disease progression. Diabetes induces imbalance in neurotrophins by increasing its proform, which is associated with upregulation of the p75(NTR) receptor in the retina. A growing body of evidence support...Continue Reading

Citations

May 24, 2018·The European Journal of Neuroscience·Paula V SubiradaMaría C Sánchez
Jan 27, 2018·Molecular Neurobiology·Mahendra Pratap KashyapPradeep Tyagi
Apr 17, 2019·Nutrients·Maria Grazia Rossino, Giovanni Casini
Oct 6, 2017·Expert Review of Ophthalmology·Sally L Elshaer, Azza B El-Remessy
Aug 31, 2016·Expert Opinion on Drug Delivery·Mary JosephAshim K Mitra
Jan 27, 2017·Neural Regeneration Research·Pan-Shi YanQiang Wen
Feb 9, 2021·Frontiers in Veterinary Science·Daniela E BarrazaMartin E Argañaraz
May 7, 2021·International Ophthalmology·Deepak SoniBrijesh Takkar

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