PMID: 9184262May 1, 1997Paper

Imbalance of tissue-type plasminogen activator (t-PA) and its specific inhibitor (PAI-1) in patients with rheumatoid arthritis associated with disease activity

Clinical Rheumatology
L T KopeikinaI Stavridis

Abstract

The relationship between plasma fibrinogen, D-dimer (DD), t-PA and PAI-1 and their correlation with disease activity (DA) were studied in 45 patients with rheumatoid arthritis (RA) (group B) to further understand the implication of fibrinolysis in the pathophysiology of RA. The control group constituted 24 healthy subjects (group A). A Stoke index (SI) of DA was assigned to each patient. Patients were divided into two groups: C, minimal-mild DA (SI 1-7); D, moderate-severe DA (SI 8-17). Fibrinogen was elevated in RA correlating positively with SI and CRP. Hypercoagulability counteracted by reactive fibrinolysis was inferred from a 10-fold increase of DD in group B as compared to group A. The relatively lower levels of DD in group D compared to group C and their negative correlation with SI (r(s) = -0.49, p = 0.0006) indicate the tendency of fibrinolysis to decrease with the increase of DA. Significant elevation of t-PA and PAI-1 were found in group B compared to group A. While t-PA progressively decreased with the increase of DA (r(s) = -0.45, p = 0.0019), a positive relation of PAI-1 to DA was observed (r = 0.42, p = 0.0042). A 2-fold increase of PAI-1/t-PA molar ratio in group D compared to groups A and C as well as its posit...Continue Reading

References

Mar 1, 1990·Arthritis and Rheumatism·W P Arend, J M Dayer
May 1, 1982·Seminars in Arthritis and Rheumatism·I Clemmensen, R B Andersen
Sep 1, 1993·Clinical Rheumatology·S Wållberg-JonssonS Rantapää-Dahlqvist

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Citations

Jul 26, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jakub KwiecińskiTao Jin
Feb 13, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yasuo NikiShigeki Momohara
Apr 12, 2003·The American Journal of Medicine·Daniel J BrotmanThomas S Kickler
May 18, 2010·Thrombosis Research·Beata Kwasny-KrochinAnetta Undas
Oct 23, 2012·Journal of Vascular Surgery·Jiunn-Horng KangHerng-Ching Lin
Nov 26, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Keiji MatsudaHisashi Kurosawa
Feb 18, 2014·The Journal of Rheumatology·Matteo Nicola Dario Di MinnoUNKNOWN CaRRDs Study Group
Dec 17, 2020·International Journal of Molecular Sciences·Alina D PeshkovaJohn W Weisel

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