Abstract
Distributions of peripheral blood lymphocyte subpopulations and T-cell subsets were studied in 38 patients with myasthenia gravis (MG) and 23 healthy controls. T cells were detected by rosette formation with sheep red blood cells and B cells with erythrocyte-antibody-complement (EAC) complexes. T mu cells were identified by rosette formation of T cells with Ox RBC-IgM complexes, and T gamma cells with Ox RBC-IgG complexes. The means of total lymphocyte count and active T cell percentage were marginally significantly lower in MG patients than in normal controls (0.05 less than P less than 0.1). The mean percentage of T mu cells was higher in MG patients than in controls (50.2 +/- 11.8% vs. 38.5 +/- 15.3%, P less than 0.01), whereas that of T gamma cells in the former was lower than that in the latter (20.4 +/- 7.1% vs. 27.6 +/- 6.2%, P less than 0.001). Thus, the loss of regulatory suppressor T cells and the increase of helper T cells in the patients are in favour of regarding MG as an autoimmune disease. The fact that the percentage of T gamma cells was significantly decreased in MG patients after autologus serum incubation, and that no such a phenomenon was seen in normal controls, may suggest a possible role of serum factors ...Continue Reading
References
Jul 1, 1977·The Journal of Experimental Medicine·L MorettaM D Cooper
Feb 1, 1978·Annals of Internal Medicine·T A WaldmannR S Krakauer
Dec 1, 1978·The Journal of Clinical Investigation·D Alarcón-Segovia, A Ruíz-Argüelles
Sep 20, 1979·The New England Journal of Medicine·A ShoreE W Gelfand
Aug 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·S KawanamiY Kuroiwa
Jan 1, 1976·Immunological Communications·R KermanS Stefani
Nov 1, 1977·The American Journal of Medicine·C L MastersR J Leedman
Nov 1, 1976·Neurology·J M LindstromD D Duane
Jan 1, 1976·Annals of the New York Academy of Sciences·B KozinerV P Perlo
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Dec 12, 1974·The New England Journal of Medicine·N I AbdouA S Penn
Oct 4, 1974·Science·R R AlmonS H Appel
May 1, 1973·The Journal of Clinical Investigation·J Wybran, H H Fudenberg
Apr 1, 1973·Neurology·E KottA H Rule
Jul 1, 1974·The Journal of Experimental Medicine·M GreavesM Doenhoff
Jan 26, 1966·Annals of the New York Academy of Sciences·M M AdnerW Dameshek
Jan 26, 1966·Annals of the New York Academy of Sciences·J A Simpson
Feb 1, 1980·Journal of the Neurological Sciences·M GalliG Scarlato
May 8, 1980·The New England Journal of Medicine·M C DalakasA L Goldstein
Citations
Jan 1, 1995·Surgery Today·M KobayashiK Kannari
Dec 1, 1982·Italian Journal of Neurological Sciences·G IppolitiP Pinelli
Jan 1, 1989·Journal of the Neurological Sciences·H SomerE Kinnunen
Aug 1, 1997·Journal of Neuroimmunology·F LicastroR D'Alessandro
Oct 2, 2012·Artificial Organs·Pei-Ju ChienHou-Chang Chiu
Apr 1, 1983·Annals of Neurology·V IyerG M Fenichel