IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations.

BMC Bioinformatics
Thierry-Pascal BaumJacques Demongeot

Abstract

Adaptative immune repertoire diversity in vertebrate species is generated by recombination of variable (V), diversity (D) and joining (J) genes in the immunoglobulin (IG) loci of B lymphocytes and in the T cell receptor (TR) loci of T lymphocytes. These V-J and V-D-J gene rearrangements at the DNA level involve recombination signal sequences (RSS). Whereas many data exist, they are scattered in non specialized resources with different nomenclatures (eg. flat files) and are difficult to extract. IMGT/GeneInfo is an online information system that provides, through a user-friendly interface, exhaustive information resulting from the complex mechanisms of T cell receptor V-J and V-D-J recombinations. T cells comprise two populations which express the alphabeta and gammadelta TR, respectively. The first version of the system dealt with the Homo sapiens and Mus musculus TRA and TRB loci whose gene rearrangements allow the synthesis of the alphabeta TR chains. In this paper, we present the second version of IMGT/GeneInfo where we complete the database for the Homo sapiens and Mus musculus TRG and TRD loci along with the introduction of a quality control procedure for existing and new data. We also include new functionalities to the fo...Continue Reading

References

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Dec 19, 2003·Nucleic Acids Research·Thierry-Pascal BaumJacques Demongeot
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David GerberPablo Pereira
Dec 21, 2004·Nucleic Acids Research·Véronique GiudicelliMarie-Paule Lefranc
Dec 21, 2004·Nucleic Acids Research·Marie-Paule LefrancGérard Lefranc
Dec 31, 2005·Nucleic Acids Research·Véronique GiudicelliMarie-Paule Lefranc
Nov 4, 2008·Nucleic Acids Research·Marie-Paule LefrancPatrice Duroux

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Citations

Jul 16, 2009·Médecine sciences : M/S·Jacques Demongeot
Nov 4, 2008·Nucleic Acids Research·Marie-Paule LefrancPatrice Duroux
Nov 4, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Lamia AbbasNicolas Glade
Jan 30, 2010·International Journal of Molecular Sciences·Jacques DemongeotLaurent Vial
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
Nov 23, 2011·European Journal of Immunology·Hang-Phuong PhamGilles Marodon
Jun 3, 2011·Cold Spring Harbor Protocols·Marie-Paule Lefranc

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Software Mentioned

LocusView
IMGT
JunctionAnalysis
GeneInfo
QUEST

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