PMID: 8592249Sep 1, 1995Paper

Imidapril hydrochloride in essential hypertension: a double-blind comparative study using enalapril maleate as a control

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
T SarutaK Ito

Abstract

To assess the value of using imidapril hydrochloride (ACE/TA-6366), a long-acting angiotensin converting enzyme (ACE) inhibitor developed in Japan, to treat patients with essential hypertension. A double-blind, comparative, phase III study was carried out using enalapril maleate as a control, with a 4-week observation period and a 12-week treatment period. Both drugs were started at a dose of 5 mg once a day, increasing to 10 mg in patients whose antihypertensive response was insufficient after 4 weeks. The study included 231 outpatients aged 30-74 years; of these, 108 in the imidapril group and 115 in the enalapril group were assessed. There were no differences in background factors between groups. An adequate antihypertensive effect was observed in 71.3% (77/108) in the imidapril group in in 66.1% (76/115) in the enalapril group, with no significant difference between groups. The pulse rate was unchanged in both groups. The drug had no adverse effects in 86.1% (93/108) of the imidapril group and 79.1% (91/115) of the enalapril group, with no significant difference between groups. Adverse drug effects were observed din 5.6% (6/108) of the imidapril group and 12.2% (14/115) of the enalapril group. Cough was the most frequent si...Continue Reading

Citations

Sep 30, 1996·The American Journal of Medicine·K Jamerson, V DeQuattro
Jan 16, 1998·European Journal of Pharmacology·S MatsubaraK Ikezawa
Dec 19, 1998·Journal of the American College of Cardiology·D J van VeldhuisenH J Crijns
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koh-ichi SakamotoAkio Fujimura
Jul 22, 1998·Lancet·T AraiH Fujiwara
Sep 12, 2012·European Journal of Internal Medicine·Xavier BoschAlfons López-Soto
Nov 3, 2010·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
Oct 24, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Thatchai Kampitak
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·E MiyajimaM Ishii

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