PMID: 9655601Jul 9, 1998Paper

Imidazoline receptor proteins in brains of patients with Alzheimer's disease

Neuroscience Letters
J A García-SevillaJ Guimón

Abstract

Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [3H]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the I2-imidazoline receptor located in mitochondria of glial (astrocyte) cells.

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Citations

Aug 19, 1999·Brain Research Bulletin·C Farsang, J Kapocsi
Oct 11, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F SaczewskiJ Saczewski
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Feb 15, 2019·Journal of Neural Transmission·Heather WilsonMarios Politis
Sep 22, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Stuart P McCluskeyOliver Howes
Nov 22, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christian Griñán-FerréMercè Pallàs
Jul 23, 1999·Annals of the New York Academy of Sciences·J A García-SevillaJ Guimón
Apr 24, 2021·Molecular Psychiatry·Amit KumarAgneta Nordberg
Dec 12, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Steven KealeyAntony D Gee
Mar 11, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robin J TyackeDavid J Nutt
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Dec 29, 2016·ACS Chemical Neuroscience·Sònia AbásCarmen Escolano
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Aug 13, 2011·Nuclear Medicine and Biology·Kazunori KawamuraMing-Rong Zhang
Nov 30, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Raquel TonelloMaribel Antonello Rubin

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