Imidazolium compounds are active against all stages of Trypanosoma cruzi

International Journal of Antimicrobial Agents
Paula Faral-TelloCarlos Robello

Abstract

Imidazolium salts are best known for their applications in organic synthesis as room-temperature ionic liquids, or as precursors of stable carbenes, but they also show important biological properties such as anti-oxidative effects, induction of mitochondrial membrane permeabilisation and inhibition of the infection cycle of Plasmodium falciparum. For these reasons, and since chemotherapy for Chagas disease is inefficient, the aim of this study was to test the use of imidazolium compounds against the kinetoplastid haemoflagellate aetiological agent for this disease, namely Trypanosoma cruzi. The results show that five of the tested compounds are more effective than the reference drug benznidazole against the epimastigote and trypomastigote forms of T. cruzi. Moreover, intracellular amastigotes were also affected by the compounds, which showed lower toxicity in host cells. Transmission electron microscopy analysis demonstrated that the tested agents induced alterations of the kinetoplast and particularly of the mitochondria, leading to extraordinary swelling of the organelle. These results further demonstrate that the test agents with the best profile are those bearing symmetrical bulky substituents at N(1) and N(3), displaying p...Continue Reading

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Citations

Jan 4, 2017·Organic & Biomolecular Chemistry·J Gravel, A R Schmitzer
Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ouldouz GhashghaeiRodolfo Lavilla
Feb 18, 2021·Current Pharmaceutical Design·Aline A Zuma, Wanderley de Souza

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