Iminosugars from Baphia nitida Lodd

Phytochemistry
Atsushi KatoR J Nash

Abstract

Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-beta-D-fructofuranoside of DMDP, and this plant produced 3-O-beta-D-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of beta-glucosidase and beta-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice alpha-glucosidase and rat intestinal maltase.

References

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Citations

Dec 31, 2011·Analytical and Bioanalytical Chemistry·Susana AmézquetaJosep Lluís Torres
Sep 3, 2013·Bioorganic & Medicinal Chemistry·Ren-Yi YanRuo-Yun Chen
Dec 29, 2012·Journal of Agricultural and Food Chemistry·Atsushi KatoFumihiro Ishikawa
Jun 28, 2011·BMC Bioinformatics·Qian ZhuDavid J Wild
Mar 8, 2016·Talanta·Susana Amézqueta, Josep Lluís Torres
Mar 8, 2013·ChemMedChem·Andreas F G GlawarGeorge W J Fleet
Nov 26, 2014·Natural Product Research·Hai-Yang JiaBo Zuo
May 18, 2016·Organic & Biomolecular Chemistry·Ying-Ying SongChu-Yi Yu
Nov 15, 2008·Journal of Natural Products·Philomène A Yao-KouassiMonique Zèches-Hanrot

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