Imipenem/cilastatin (1.5 g daily) versus meropenem (3.0 g daily) in patients with intra-abdominal infections: results of a prospective, randomized, multicentre trial

Scandinavian Journal of Infectious Diseases
A BasoliV Speranza

Abstract

An open-label prospective, randomized, parallel multicentre study was undertaken to compare the efficacy and tolerability of 1.5 g/day intravenous imipenem/cilastatin with 3 g/day intravenous meropenem in the treatment of intra-abdominal infections. A total of 287 patients were enrolled: 201 patients, divided between the 2 treatment groups, were evaluable. Clinical outcome, bacteriological outcome, untoward microbiological effects, and clinical and laboratory adverse experiences were evaluated. 98% of patients receiving imipenem/cilastatin therapy were cured, with 96% showing eradication of infection. 95% of those on meropenem were cured, with 98% showing eradication. These differences in clinical and bacteriological outcome between the 2 treatments were not statistically significant. Two patients receiving imipenem/cilastatin and 5 receiving meropenem had untoward microbiological effects. There was a 0.7% frequency (1/139 patients) of possibly or probably drug-related clinical or laboratory adverse experiences with imipenem/cilastatin and a 2.7% frequency (4/148) with meropenem. The mean time to defervescence was significantly less for patients in the imipenem/cilastatin treatment group than for those receiving meropenem. This...Continue Reading

References

Apr 1, 1989·Antimicrobial Agents and Chemotherapy·R N JonesM A Pfaller
Dec 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M R VisserJ Verhoef
Feb 1, 1988·Archives of Surgery·J M BohnenB D Schouten
Nov 1, 1985·Reviews of Infectious Diseases·R L Nichols
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jul 1, 1985·Reviews of Infectious Diseases·H KroppF M Kahan
Dec 1, 1983·The Journal of Antimicrobial Chemotherapy·S R NorrbyK H Jones
Jan 1, 1995·The Journal of Antimicrobial Chemotherapy·B BrismarT Skau
Sep 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R E CondonS E Wilson
Jul 1, 1995·The Journal of Antimicrobial Chemotherapy·J R Edwards
Feb 1, 1996·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T ToyoguchiH Watanabe
Apr 1, 1996·Antimicrobial Agents and Chemotherapy·R WhiteJ Bosso

❮ Previous
Next ❯

Citations

Jan 24, 2006·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Steven J EdwardsJonathan M Plumb
Sep 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Antonio BasoliUNKNOWN Italian Study Group
Dec 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Kemal TurkyilmazAyse Erturk
Aug 26, 1998·International Journal of Antimicrobial Agents·B A Cunha
Jan 25, 2003·Surgical Infections·John E MazuskiUNKNOWN Therapeutic Agents Committee of the Surgical Infections Society
Jan 25, 2003·Surgical Infections·John E MazuskiUNKNOWN Therapeutic Agents Committee of the Surgical Infections Society
Oct 6, 2005·Surgical Infections·Jose M Tellado, Samuel E Wilson
May 7, 2002·Critical Care Medicine·Per SandvenUNKNOWN NORGAS Group and the Norwegian Yeast Study Group
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinUNKNOWN Infectious Diseases Society of America
Apr 20, 2014·The Journal of Antimicrobial Chemotherapy·Joan P CannonShellee A Grim
Mar 13, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P KujathA Rodloff
Feb 26, 2013·Journal of Chemotherapy·Dominique BreilhEmmanuel Boselli
Jun 23, 2005·Current Medical Research and Opinion·Steven J EdwardsHelen E Campbell
Oct 18, 2000·Pediatric Hematology and Oncology·C KaradenizA Serdaroğlu
Apr 28, 2007·International Journal of Surgery·Peter FominUNKNOWN Three Hundred Six Study Group
Apr 23, 2005·The Cochrane Database of Systematic Reviews·P F WongD J Leaper
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Sep 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John F Mohr
Dec 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiuwen WuJianan Ren
Apr 9, 2002·Journal of Chemotherapy·S Colizza, S Rossi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.