Abstract
Surgical resection of lentigo maligna (LM) is complicated by noncontiguous, subclinical extension and actinic melanocytic hyperplasia in sun-damaged skin of older individuals. We sought to determine the long-term effectiveness of imiquimod as primary or adjuvant therapy for LM. Patients were retrospectively identified from January 1, 2003, to December 31, 2013, with LM, early/evolving LM, and LM melanoma who had used topical imiquimod 5% cream for either primary therapy after diagnostic biopsy, or adjuvant therapy after narrow-margin surgical resection or complete clinical but not histologic resection of LM. Follow-up occurred through December 31, 2014. In all, 63 cases were identified in 61 patients, mean (SD) age 71.1 (12.4) years; 58 were analyzed for local recurrence. Imiquimod was used as primary therapy in 22 of 63 (34.9%) and adjuvant therapy in 41 of 63 (65.1%) for mean duration of 11.7 (range 2-60) weeks. Fifty cases (86.2%) demonstrated clinical clearance at mean (SD) follow-up of 42.1 (27.4) months: 72.7% primary and 94.4% adjuvant at 39.7 (23.9) and 43.1 (28.9) months, respectively. Retrospective cohort study and lack of standardized imiquimod application are limitations. Imiquimod cream appears to be a viable optio...Continue Reading
References
Mar 1, 1987·The British Journal of Dermatology·M A Weinstock, A J Sober
Feb 1, 1993·The American Journal of Dermatopathology
Jan 29, 2003·British Journal of Plastic Surgery·J E Osborne, P E Hutchinson
Nov 18, 2003·The British Journal of Dermatology·M F NaylorR L Cornelison
Apr 20, 2005·Archives of Dermatology·Ingrid H WolfHelmut Kerl
Sep 28, 2005·The Journal of Investigative Dermatology·Susan M SwetterJeff D Harvell
May 20, 2008·Journal of the American Academy of Dermatology·Seth B FormanDirk M Elston
Jul 23, 2008·Archives of Dermatology·Urs V BuettikerRobert E Hunger
Sep 25, 2008·Annals of Plastic Surgery·Mary-Helen MahoneyClaire Temple
Feb 19, 2009·The British Journal of Dermatology·A M PowellR J Barlow
Dec 3, 2009·Plastic and Reconstructive Surgery·Mark W BosbousMarcelle Neuburg
Feb 18, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lixia Z EllisLeslie Stewart
Oct 16, 2012·Journal of the American Academy of Dermatology·Douglas GrossmanGlen M Bowen
Jan 1, 2014·Journal of the American Academy of Dermatology·Sultan A MirzoyevRandall K Roenigk
Citations
Nov 12, 2015·Pharmacogenomics·Stefano PiasericoMauro Alaibac
Dec 1, 2015·The British Journal of Dermatology·K GrevelingE P Prens
Nov 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D CrisanL A Schneider
Oct 8, 2016·The British Journal of Dermatology·J R MarsdenUNKNOWN NCRI Skin Cancer Clinical Studies Group, the U.K. Dermatology Clinical Trials Network and the LIMIT-1 Collaborative Group
Dec 18, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D TioC van Montfrans
May 16, 2017·The British Journal of Dermatology·S M Swetter
Feb 13, 2018·The Journal of Dermatology·Clara Matas-NadalRosa M Martí
May 31, 2018·JAMA Dermatology·Jessica M DoniganGlen M Bowen
May 31, 2018·JAMA Dermatology·Scott W FoskoKishwer S Nehal
Sep 22, 2018·Biomedical Chromatography : BMC·Vanessa F M CarvalhoLuciana B Lopes
Feb 8, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C Navarrete-DechentK S Nehal
Aug 30, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Blake P Sampson, Glen M Bowen
Apr 3, 2020·Journal of Immunotherapy·Joel C SunshineJennifer N Choi
Feb 16, 2018·Dermatology Practical & Conceptual·Caroline ColmantIsabelle Tromme
Oct 24, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Courtney J EnsslinAnthony M Rossi
Jun 29, 2018·Current Treatment Options in Oncology·Yoshiyuki Nakamura, Yasuhiro Fujisawa
Jan 22, 2019·Clinical and Experimental Dermatology·M Papanikolaou, C M Lawrence
Jul 28, 2020·International Journal of Dermatology·Valeria CocoKetty Peris
Mar 23, 2018·Immunotherapy·Magdalena VolaMaría Moreno
Aug 2, 2018·Annals of Dermatology·Na Hee KimSook Jung Yun
Mar 12, 2019·Annals of Plastic Surgery·Cynthia TsayDeepak Narayan
Jan 7, 2021·The AAPS Journal·Supreeda TambunlertchaiAliasger K Salem
Dec 24, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Res
Nov 24, 2020·Clinical, Cosmetic and Investigational Dermatology·Helena IznardoOriol Yélamos
Feb 19, 2021·Science Translational Medicine·Jennifer A LoDavid E Fisher
Jun 3, 2020·Surgical Oncology Clinics of North America·Joseph G CromptonEdmund K Bartlett
Jul 29, 2021·The Journal of Dermatological Treatment·R KwakH C Tsibris
Apr 25, 2021·The British Journal of Dermatology·A LallasG Argenziano
Oct 31, 2021·Journal for Immunotherapy of Cancer·Tejus SatishAngela J Yoon