Imiquimod 5% cream as primary or adjuvant therapy for melanoma in situ, lentigo maligna type

Journal of the American Academy of Dermatology
Susan M SwetterBarbara M Egbert

Abstract

Surgical resection of lentigo maligna (LM) is complicated by noncontiguous, subclinical extension and actinic melanocytic hyperplasia in sun-damaged skin of older individuals. We sought to determine the long-term effectiveness of imiquimod as primary or adjuvant therapy for LM. Patients were retrospectively identified from January 1, 2003, to December 31, 2013, with LM, early/evolving LM, and LM melanoma who had used topical imiquimod 5% cream for either primary therapy after diagnostic biopsy, or adjuvant therapy after narrow-margin surgical resection or complete clinical but not histologic resection of LM. Follow-up occurred through December 31, 2014. In all, 63 cases were identified in 61 patients, mean (SD) age 71.1 (12.4) years; 58 were analyzed for local recurrence. Imiquimod was used as primary therapy in 22 of 63 (34.9%) and adjuvant therapy in 41 of 63 (65.1%) for mean duration of 11.7 (range 2-60) weeks. Fifty cases (86.2%) demonstrated clinical clearance at mean (SD) follow-up of 42.1 (27.4) months: 72.7% primary and 94.4% adjuvant at 39.7 (23.9) and 43.1 (28.9) months, respectively. Retrospective cohort study and lack of standardized imiquimod application are limitations. Imiquimod cream appears to be a viable optio...Continue Reading

References

Mar 1, 1987·The British Journal of Dermatology·M A Weinstock, A J Sober
Jan 29, 2003·British Journal of Plastic Surgery·J E Osborne, P E Hutchinson
Nov 18, 2003·The British Journal of Dermatology·M F NaylorR L Cornelison
Apr 20, 2005·Archives of Dermatology·Ingrid H WolfHelmut Kerl
Sep 28, 2005·The Journal of Investigative Dermatology·Susan M SwetterJeff D Harvell
May 20, 2008·Journal of the American Academy of Dermatology·Seth B FormanDirk M Elston
Jul 23, 2008·Archives of Dermatology·Urs V BuettikerRobert E Hunger
Sep 25, 2008·Annals of Plastic Surgery·Mary-Helen MahoneyClaire Temple
Dec 3, 2009·Plastic and Reconstructive Surgery·Mark W BosbousMarcelle Neuburg
Feb 18, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lixia Z EllisLeslie Stewart
Oct 16, 2012·Journal of the American Academy of Dermatology·Douglas GrossmanGlen M Bowen
Jan 1, 2014·Journal of the American Academy of Dermatology·Sultan A MirzoyevRandall K Roenigk

❮ Previous
Next ❯

Citations

Nov 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D CrisanL A Schneider
Oct 8, 2016·The British Journal of Dermatology·J R MarsdenUNKNOWN NCRI Skin Cancer Clinical Studies Group, the U.K. Dermatology Clinical Trials Network and the LIMIT-1 Collaborative Group
Aug 30, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Blake P Sampson, Glen M Bowen
Feb 16, 2018·Dermatology Practical & Conceptual·Caroline ColmantIsabelle Tromme
Oct 24, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Courtney J EnsslinAnthony M Rossi
Jun 29, 2018·Current Treatment Options in Oncology·Yoshiyuki Nakamura, Yasuhiro Fujisawa
Jan 22, 2019·Clinical and Experimental Dermatology·M Papanikolaou, C M Lawrence
Jul 28, 2020·International Journal of Dermatology·Valeria CocoKetty Peris
Jan 7, 2021·The AAPS Journal·Supreeda TambunlertchaiAliasger K Salem
Dec 24, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Res
Nov 24, 2020·Clinical, Cosmetic and Investigational Dermatology·Helena IznardoOriol Yélamos
Jun 3, 2020·Surgical Oncology Clinics of North America·Joseph G CromptonEdmund K Bartlett
Jul 29, 2021·The Journal of Dermatological Treatment·R KwakH C Tsibris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
U Borucki, D Metze
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Tim van MeursGudula Kirtschig
© 2021 Meta ULC. All rights reserved