Immature and mature neurons coexist among glial scars after rat traumatic brain injury

Neurological Research
Tatsuki ItohHiroyuki Ito

Abstract

Glial scars around a damaged area after brain injury inhibit neurite elongation from surviving neurons and axonal plasticity, and thus prevent neural network regeneration. However, the generation, differentiation and maturation of neural stem cells (NSCs) among glial scars after brain injury have not yet been reported. In the present study, we investigated the chronological relationship between gliosis and maturation of new neurons around a damaged area using a rat traumatic brain injury (TBI) model. Between 1 and 7 days after injury, many nestin-positive cells were observed around the damaged area. Three days after injury, many small nestin-positive cells showed an astrocytic morphology. Between 1 and 30 days after injury, doublecortin (DCX)-positive cells were present around the damaged area. Three and 7 days after injury, a small number of nestin-positive cells were immunopositive for glial fibrillary acidic protein (GFAP). Seven days after injury, there were DCX-positive cells in the gliosis occurring in the lesion. Thirty days after injury, DCX-positive cells were observed near and among the glial scars and a small number of these cells were immunopositive for NeuN. These results suggest that DCX-positive cells were presen...Continue Reading

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Citations

Sep 8, 2012·Journal of Neural Transmission·Tatsuki ItohTakao Satou
Mar 17, 2009·Journal of Neural Engineering·E K PurcellD R Kipke
Mar 30, 2012·Neuro-Signals·Nicole ByeM Cristina Morganti-Kossmann
Feb 21, 2009·Neurological Research·Tatsuki ItohHiroyuki Ito
May 4, 2011·Stem Cell Reviews and Reports·Kristien ReekmansPeter Ponsaerts
Oct 7, 2008·Epilepsy & Behavior : E&B·Asla Pitkänen, Katarzyna Lukasiuk
Aug 19, 2011·Leukemia Research·Antonio ChiarettiRiccardo Riccardi
Jan 8, 2017·Journal of Cellular Physiology·Sanshiro KanazawaKazuto Hoshi
Oct 21, 2006·Neurochemical Research·Tatsuki ItohHiroyuki Ito
Jul 12, 2019·Frontiers in Molecular Neuroscience·Nissrine BalloutAfsaneh Gaillard

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