Immature Citrus reticulata Extract Promotes Browning of Beige Adipocytes in High-Fat Diet-Induced C57BL/6 Mice

Journal of Agricultural and Food Chemistry
Ya-Chun ChouMin-Hsiung Pan

Abstract

Obesity has become a global public health issue. Promoting browning of white adipose tissue (WAT) helps to maintain energy homeostasis. Previous studies have found that citrus fruit exhibits a number of biological activities. Although most citrus fruit drop has been considered agricultural waste, the ability to use it may be desirable. In this study, we investigate the antiobesity effects of immature citrus fruits in high-fat diet (HFD)-fed mice. The main phytochemical components of immature Citrus reticulata in water extraction analyzed by HPLC are synephrine, narirutin, hesperidin, nobiletin, and tangeretin (16.0 ± 1.08, 4.52 ± 0.31, 9.14 ± 0.32, 2.54 ± 0.07, 1.67 ± 0.05 mg/g, respectively). Oral administration of 1% immature Citrus reticulata extract (ICRE) for 11 weeks markedly reduced body weight gain, epididymal fat weight, fasting blood glucose, serum triglyceride, and total cholesterol ( P < 0.05 for all). In addition, histological analysis revealed that dietary ICRE decreased adipocyte size and hepatic steatosis compared to the HFD group ( P < 0.05 for both). Furthermore, we found that mice treated with ICRE have improved cold tolerance during acute cold challenge. These effects were associated with increased expressio...Continue Reading

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Citations

Apr 25, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Milad AshrafizadehElham Ghasemipour Afshar
Dec 5, 2019·International Journal of Molecular Sciences·Silvia Lorente-CebriánHeriberto Castro
Aug 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanbing LiLinghuan Li
Jan 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guangning KouQuanjun Lyu
Mar 7, 2021·Antioxidants·Min-Kyeong LeeChoon Young Kim
May 8, 2021·Journal of Complementary & Integrative Medicine·Yung-Kai LinChi-Fu Chiang

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