PMID: 9525591Apr 3, 1998Paper

Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells

Journal of Virology
A Granelli-PipernoR M Steinman

Abstract

Dendritic cells (DCs) can develop from CD14+ peripheral blood monocytes cultured in granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). By 6 days in culture, the cells have the characteristics of immature DCs and can be further induced to mature by inflammatory stimuli or by monocyte-conditioned medium. After infection with macrophagetropic (M-tropic) human immunodeficiency virus type 1 (HIV-1), monocytes and mature DCs show a block in reverse transcription and only form early transcripts that can be amplified with primers for the R/U5 region. In contrast, immature DCs cultured for 6 or 11 days in GM-CSF and IL-4 complete reverse transcription and show a strong signal when LTR/gag primers are used. Blood monocytes and mature DCs do not replicate HIV-1, whereas immature DCs can be productively infected, but only with M-tropic HIV-1. The virus produced by immature DCs readily infects activated T cells. Although mature DCs do not produce virus, these cells transmit both M- and T-tropic virus to T cells. In the cocultures, both DCs and T cells must express functional chemokine coreceptors for viral replication to occur. Therefore, the developmental stage of DCs can influence the interaction of these ...Continue Reading

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Citations

Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·B LeeR W Doms
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Granelli-PipernoR M Steinman
Mar 8, 2002·Clinical and Experimental Immunology·T H J MacDougallD R Katz
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralph Marvin Steinman, Michel C Nussenzweig
Jul 19, 2002·The Journal of General Virology·Paul R Clapham, Aine McKnight
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Karin Lore, Marie Larsson
Nov 25, 2003·Blood·Stuart G TurvilleAnthony L Cunningham
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Angela Granelli-PipernoRalph M Steinman
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Doris WilflingsederHeribert Stoiber
Dec 21, 2004·Springer Seminars in Immunopathology·Marie Larsson
Dec 16, 2005·The AAPS Journal·Madhavan P N NairDon Sykes
Aug 23, 2006·Journal of Leukocyte Biology·Heather DonaghyAnthony L Cunningham
Oct 26, 2006·Nature Reviews. Immunology·Li Wu, Vineet N KewalRamani
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline GilbertMichel J Tremblay
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Jul 11, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laurence VachotMelissa Robbiani
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Sep 16, 2006·Immunological Reviews·Yuri Persidsky, Larisa Poluektova

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