Immature granulocytes index as early marker of sepsis

International Journal of Laboratory Hematology
Laura S AyresTerezinha P Munhoz

Abstract

Sepsis induces the recruitment of immature neutrophils into the circulation. An immature granulocyte percentage (IG%) count greater than 3% has been shown to be an indicator for the risk of sepsis. The aim of this study was to evaluate the IG% as predictor of sepsis compared to blood culture results and sepsis diagnostic confirmation. The study included individuals (n = 301) of both sexes aged ≥18 years who underwent Hospital São Lucas examinations between January and November 2017. For all the patients, IG%, as well as blood culture results, were evaluated. All examinations were obtained from Clinical Laboratory database. Data were analyzed through the SPSS program version 18.0. There was statistical association between blood culture and IG% results (P = 0.009) and between sepsis confirmation and IG% on Pearson chi-square test (P < 0.001). An IG% cutoff point of 2.0% was able to exclude sepsis based on clinical diagnosis with a specificity of 90.9% and a sensitivity of 38.5%. The cutoff value in ROC analyses of IG% based on blood culture results was 0.3% and 0.4% based on clinical diagnosis. Our study demonstrated that IG% <2.0% are helpful on the exclusion of sepsis diagnosis with a very high specificity (90.9%). The IG% is a...Continue Reading

Associated Clinical Trials

References

Sep 23, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Larry H Bernstein, James Rucinski
Oct 2, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chang Hoon LeeKyung-A Lee
Feb 12, 2014·The American Journal of Emergency Medicine·Mohammad NaffaaWalid Saliba
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Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jun 25, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jae Hyon ParkJae Il Shin

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Citations

Oct 22, 2019·The Lancet Infectious Diseases·Ignacio RubioJesús F Bermejo-Martín
Feb 3, 2021·International Journal of Laboratory Hematology·Ali GüngörCan Demir Karacan
Mar 30, 2020·The American Journal of Emergency Medicine·Serkan KarakulakEnver Üçbilek
Oct 9, 2021·International Journal of Laboratory Hematology·Alexandra MyariChristina Tsaousi

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