PMID: 19132202Jan 10, 2009Paper

Immature platelets in patients with acute coronary syndromes

Thrombosis and Haemostasis
Erik Lerkevang GroveS D Kristensen

Abstract

Platelets newly released from the bone marrow are RNA-containing and more haemostatically active than mature platelets. Immature platelets are reliably quantified by flow cytometry, and the immature platelet fraction (IPF) reflects platelet production and the rate of platelet turnover. It was the objective of this study to evaluate the presence of immature platelets in healthy subjects, patients with stable coronary artery disease (CAD) and patients with acute coronary syndromes. Flow cytometric determination of immature platelets was performed with an automated analyzer (Sysmex XE-2100) using RNA fluorescent dyes. IPF was determined in 420 individuals: 22 healthy subjects, 39 patients with stable CAD, 182 patients with unstable angina/non-ST-segment elevation myocardial infarction (non-STEMI) and 177 patients with acute STEMI. The geometric mean [95% confidence interval] of IPF was 2.51 [2.04-3.10] in healthy subjects, 2.87 [2.45-3.36] in CAD patients, 2.93 [2.72-3.15] in the non-STEMI/unstable angina group and 3.71 [3.45-3.99] in patients with STEMI (ANOVA: p < 0.0001). This difference remained significant after adjusting for baseline characteristics (p = 0.0003). In active smokers, IPF was 18% higher than in non-smoking indi...Continue Reading

Citations

Dec 18, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Giuseppe PattiGermano Di Sciascio
Jun 11, 2015·Journal of Ophthalmology·Hande GucluRamazan Birgul
Aug 16, 2011·Thrombosis Research·Morten WürtzAnne-Mette Hvas
Feb 7, 2018·Drug Metabolism and Personalized Therapy·Dagmar F Hernandez-SuarezJorge Duconge
Oct 31, 2017·Angiology·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Mar 11, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ivy Susanne ModrauAnne-Mette Hvas
Mar 14, 2019·Journal of Cardiovascular Medicine·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
May 20, 2009·Future Cardiology·Erik L Grove, Steen D Kristensen
Oct 20, 2010·Journal of Thrombosis and Haemostasis : JTH·E L GroveS D Kristensen
Oct 15, 2010·Journal of Thrombosis and Haemostasis : JTH·J KlovaiteB G Nordestgaard
Jul 9, 2011·Platelets·Valery M PogorelovMarina A Skedina
Aug 24, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Ebru TekbasMehmet S Ulgen
Dec 27, 2011·Journal of Thrombosis and Thrombolysis·Homam IbrahimNeal S Kleiman
May 1, 2012·Journal of Thrombosis and Haemostasis : JTH·M Lordkipanidzé, P Harrison
Sep 28, 2012·Thrombosis and Haemostasis·Patrizia FerroniGiovanni Davì
Dec 12, 2012·Platelets·Kristian Løkke Funck-JensenSteen Dalby Kristensen
Jul 23, 2014·Cardiology in Review·Ilaria CavallariGermano Di Sciascio
Sep 12, 2014·Thrombosis and Haemostasis·E L GroveS D Kristensen
Jun 21, 2016·International Journal of Laboratory Hematology·A PecoraroM Gioia
Jun 24, 2017·Coronary Artery Disease·Homam Ibrahim, Neal S Kleiman
Oct 30, 2019·European Journal of Clinical Investigation·Matteo NardinGiuseppe De Luca
Jan 17, 2020·Diabetes/metabolism Research and Reviews·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)
Apr 14, 2020·Circulation·Suzanne V ArnoldUNKNOWN American Heart Association Council on Lifestyle and Cardiometabolic Health and Council on Clinical Cardiology
Feb 10, 2011·Therapeutic Advances in Cardiovascular Disease·Mamta H BuchRobert F Storey
Jun 10, 2011·Thrombosis and Haemostasis·Andrew DarlingtonDominick J Angiolillo
Jun 29, 2012·Clinical Cardiology·Jonathan Grinstein, Christopher P Cannon
Sep 19, 2012·Nature Reviews. Cardiology·John F MartinFizzah A Choudry
Nov 13, 2012·Wiener medizinische Wochenschrift·Matthias K FreynhoferKurt Huber
May 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Laura HilleDietmar Trenk

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