PMID: 9438661Jan 23, 1998Paper

Immature tubules are tolerant of oxygen deprivation

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
K M GaudioN J Siegel

Abstract

The tolerance of immature tissues to injury has been noted over the past several decades. Traditional teaching relates this tolerance to energy derived from anaerobic glycolysis. This mini-review describes investigations of the hypothesis that the immature kidney is less susceptible to oxygen deprivation than the mature kidney. Utilizing proximal tubule suspensions from immature and mature rats, studies assessing ATP levels as an index of cellular energy and lactate dehydrogenase (LDH) release as a determinant of plasma membrane damage demonstrate the developing kidney is resistant to prolonged anoxia. ATP is maintained at twofold higher levels during anoxia in the immature tubule compared with the mature tubule. The contribution of anaerobic glycolysis to the tolerance of the immature renal tubules is investigated by two inhibitors of the glycolytic pathway, L-glucose and iodoacetate. Following 70%-90% inhibition of glycolysis, ATP is decreased to similar levels in immature and mature tubules. However, immature tubules remain resistant to anoxic damage with no significant change in LDH release. Therefore, enhanced glycolytic activity does not play a dominant role in the tolerance of the developing kidney to anoxia, and this to...Continue Reading

Citations

Mar 4, 2000·Clinical and Experimental Pharmacology & Physiology·K J GibsonE R Lumbers
Dec 10, 2003·Pediatric Research·Shinsuke AdachiUlla Holtback
Jun 19, 2021·Seminars in Fetal & Neonatal Medicine·Jeffrey L SegarUNKNOWN Newborn Brain Society Guidelines and Publications Committee
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Z ZhangF Ismail-Beigi

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