Immature/transitional B-cell expansion is associated with bone loss in HIV-infected individuals with severe CD4+ T-cell lymphopenia.

AIDS
Kehmia TitanjiM Neale Weitzmann

Abstract

Antiretroviral therapy (ART) has led to a significant decline in HIV-related morbidity and mortality in people living with HIV (PLWH). PLWH however experience non-AIDS ageing-associated comorbidities, including decreased bone mass and osteoporosis, earlier and more severely, than uninfected people. We previously reported that total B-cell production of the key osteoclastogenic cytokine receptor activator of NF-κB ligand (RANKL) was elevated in PLWH, concurrent with a decrease in total B-cell production of RANKL's physiological moderator Osteoprotegerin (OPG). The resulting increased total B-cell RANKL/OPG ratio was significantly associated with bone loss in the appendicular (long bones), but not axial (spine) skeletons of PLWH. A role for immature/transitional B cells (BImm) in HIV-induced bone loss has not been reported. BImm frequency was determined by flow cytometry; plasma IL-7 was quantified by ELISA and bone mineral density (BMD) measured by dual X-ray absorptiometry (DXA) in a cross-sectional study of 62 ART-naive HIV-infected and 58 HIV-negative individuals. BImm expansion correlated with the total B-cell RANKL/OPG ratio in HIV-infected individuals and inversely with BMD at the total hip, femoral neck and the lumbar spi...Continue Reading

References

Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A KanisN Khaltaev
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·C MiyauraT Suda
May 9, 2001·Blood·T J FryC L Mackall
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N ManabeM Kuro-o
Sep 28, 2001·Trends in Immunology·T J Fry, C L Mackall
Dec 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gianluca ToraldoM Neale Weitzmann
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela MalaspinaAnthony S Fauci
May 10, 2008·Arthritis Research & Therapy·Joel A G van Roon, Floris P J G Lafeber
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tatyana VikulinaM Neale Weitzmann
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Mar 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin YoungUNKNOWN HIV Outpatient Study (HOPS) Investigators
Feb 18, 2012·Blood·Kieron Dunleavy, Wyndham H Wilson
Mar 17, 2012·Seminars in Immunology·Steven A Corfe, Christopher J Paige
Aug 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip M GrantTodd T Brown
Aug 16, 2013·AIDS Care·Susan S ReifWenfeng Gong
May 20, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ighovwerha OfotokunM Neale Weitzmann
Jun 18, 2016·Nature Reviews. Endocrinology·M Neale Weitzmann, Ighovwerha Ofotokun
Mar 2, 2017·Journal of Community Health·Susan ReifKathryn Whetten
Sep 26, 2019·Frontiers in Immunology·Mohamed KhassHarry W Schroeder
Oct 18, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ighovwerha OfotokunM Neale Weitzmann

❮ Previous
Next ❯

Citations

Aug 26, 2021·Annals of Clinical Microbiology and Antimicrobials·Liang ChenXiqian Xing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chemometrics and Intelligent Laboratory Systems : an International Journal Sponsored by the Chemometrics Society
Jaime Lynn SpeiserValerie L Durkalski
Communications in Statistics: Simulation and Computation
Jaime Lynn SpeiserValerie L Durkalski
© 2021 Meta ULC. All rights reserved