PMID: 3179606Jul 1, 1988Paper

Immediate anaphylactic bronchoconstriction induces airway hyperreactivity in anaesthetized guinea-pigs

British Journal of Pharmacology
L DaffonchioB J Whittle

Abstract

1. The possible acute occurrence of airway hyperreactivity after immediate-type bronchial anaphylaxis has been investigated in anaesthetized guinea-pigs actively sensitized to ovalbumin (OA). 2. Aerosol challenge (OA 10 mg ml-1, 5 s) provoked immediate bronchoconstriction which was substantially, although incompletely, reversed by isoprenaline (Iso) infusion (1 microgram kg-1 min-1) for 10 min). 3. Bronchoconstrictor responses to 5-hydroxytryptamine (5-HT) were enhanced in challenged animals when compared to those in non-challenged animals that had also received Iso. This was seen as a leftward shift in the location of the dose-response curve for the bronchoconstrictor effect of 5-HT (dose-ratio 2.45, 95% confidence limits 1.77-3.38; P less than 0.01). This phenomenon was associated with pulmonary infiltration of polymorphonuclear leukocytes, which was not modified by Iso treatment. 4. Iso infusion alone caused a slight enhancement of airway reactivity seen as a small leftward shift of the dose-response curve for the bronchoconstrictor effect of 5-HT (dose-ratio 1.51, 95% confidence limits 1.07-2.13; P less than 0.05). 5. These results support a causal relationship between acute pulmonary inflammation and airway hyperreactivity...Continue Reading

References

Nov 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
May 1, 1986·Prostaglandins·J E Thorpe, C G Murlas
Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Jul 1, 1987·The American Review of Respiratory Disease·C GattoD E Johnson
May 1, 1987·The Journal of Allergy and Clinical Immunology·S MattoliG Ciappi
Sep 1, 1986·Journal of Autonomic Pharmacology·C OminiF Berti
Mar 1, 1987·Journal of Pharmacological Methods·A N Payne, G de Nucci
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·C Robinson, S T Holgate
Jan 1, 1984·International Archives of Allergy and Applied Immunology·P Kallós, L Kallós
Apr 8, 1983·European Journal of Pharmacology·J C WilliamsR E Giles
Jun 1, 1983·Prostaglandins, Leukotrienes, and Medicine·B R Creese, M K Bach

Citations

Feb 28, 1989·European Journal of Pharmacology·L DaffonchioB J Whittle
Aug 1, 1992·British Journal of Pharmacology·J R Thorne, K J Broadley
Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H Danahay, K J Broadley

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