Immediate and delayed effects of D-fructose upon insulin, somatostatin, and glucagon release by the perfused rat pancreas

Endocrine
Abdullah SenerW J Malaisse

Abstract

Novel information was recently provided concerning the reciprocal effects of D-glucose and D-fructose upon their respective metabolism in rat pancreatic islets. In the light of such findings, this study aims at comparing the effects of D-glucose and D-fructose on insulin, somatostatin, and glucagon release from the isolated perfused rat pancreas. A rise in D-glucose concentration from 3.3 to 5.0 or 7.3 mM or the administration of D-fructose (17 and 40 mM) in the presence of 3.3 mM D-glucose stimulated insulin release in a concentration-related manner, but failed to affect somatostatin output. The secretion of glucagon was decreased in all cases. The secretory response to L-arginine (5 mM), 25 min after restoring the basal concentration of D-glucose, was more markedly affected, in terms of potentiation of insulin and somatostatin release and reduction of glucagon output, after prior administration of D-fructose than after a prior increase in D-glucose concentration. These findings argue against any major role for a paracrine regulation of hormonal release and, instead, are consistent with a causal link between metabolic and secretory events in the islet cells. Nevertheless, the present results emphasize differences in the respon...Continue Reading

Citations

Apr 15, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christine P DiggleDavid T Bonthron
Dec 25, 2013·International Journal of Molecular Medicine·Willy J Malaisse

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