Immediate and delayed potentiating effects of tumor necrosis factor-α on TRPV1 sensitivity of rat vagal pulmonary sensory neurons

American Journal of Physiology. Lung Cellular and Molecular Physiology
Chun-Chun HsuLu-Yuan Lee

Abstract

We studied acute effects of tumor necrosis factor-α (TNFα) on the sensitivity of isolated rat vagal pulmonary sensory neurons. Our results showed the following. First, a brief pretreatment with a low dose of TNFα (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Δ = 247%) immediately following the TNFα pretreatment, which gradually declined toward control and then increased again reaching another peak (Δ = 384%) after 60-90 min. Second, the immediate phase of this potentiating effect of TNFα was completely abolished by a pretreatment with a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, whereas the delayed potentiation was only partially attenuated. Third, in sharp contrast, TNFα did not generate any potentiating effect on the responses to non-TRPV1 chemical activators of these neurons. Fourth, the selectivity of the TNFα action on TRPV1 was further illustrated by the responses to acid (pH 6.0); TNFα did not affect the rapid transient current mediated by acid-sensing ion channels but significantly augmented the slow sustained current mediated by TRPV1 in the same neuron...Continue Reading

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Citations

Jun 27, 2018·Journal of Neurotrauma·Kun-Ze Lee, Ke-Jun Xu
Apr 20, 2018·American Journal of Respiratory and Critical Care Medicine·Zheng DengKefang Lai
Aug 19, 2020·American Journal of Respiratory and Critical Care Medicine·Clare O ShapiroMatthew G Drake
Feb 16, 2021·Neuroscience Letters·Qihai Gu, Lu-Yuan Lee

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Methods Mentioned

BETA
bronchoalveolar lavage
enzyme-linked immunosorbent assay
ELISA

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