Immediate early gene activation throughout the brain is associated with dynamic changes in social context

Social Neuroscience
Cait M WilliamsonJames P Curley

Abstract

Social competence is dependent on successful processing of social context information. The social opportunity paradigm is a methodology in which dynamic shifts in social context are induced through removal of the alpha male in a dominance hierarchy, leading to rapid ascent in the hierarchy of the beta male and of other subordinate males in the social group. In the current study, we use the social opportunity paradigm to determine what brain regions respond to this dynamic change in social context, allowing an individual to recognize the absence of the alpha male and subsequently perform status-appropriate social behaviors. Replicating our previous work, we show that following removal of the alpha male, beta males rapidly ascend the social hierarchy and attain dominant status by increasing aggression towards more subordinate individuals. Analysis of patterns of Fos immunoreactivity throughout the brain indicates that in individuals undergoing social ascent, there is increased activity in regions of the social behavior network, as well as the infralimbic and prelimbic regions of the prefrontal cortex and areas of the hippocampus. Our findings demonstrate that male mice are able to respond to changes in social context and provide ...Continue Reading

References

Oct 1, 1976·Behavioral Biology·J NybyG Whitney
Apr 1, 1984·Physiology & Behavior·J J BolhuisJ M Koolhaas
Jan 1, 1982·Experimental Brain Research·D I PerrettW Caan
Mar 1, 1993·Experimental & Applied Acarology·M I Meltzer, R A Norval
Dec 22, 1999·Physiology & Behavior·L A LumleyJ L Meyerhoff
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ivan D ChaseMichael Manfredonia
Mar 4, 2003·Nature Reviews. Neuroscience·Ralph Adolphs
Jun 1, 1954·Journal of Comparative and Physiological Psychology·H E ROSVOLDK H PRIBRAM
Jan 13, 2004·The Journal of the Acoustical Society of America·Robert C LiuChristoph E Schreiner
Jul 28, 2004·Die Naturwissenschaften·Benjamin E F GourbalClaude Gabrion
May 12, 2005·Hormones and Behavior·James L Goodson
Oct 12, 2005·PLoS Biology·Sabrina S BurmeisterRussell D Fernald
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Jan 26, 2007·Nature·Logan GrosenickRussell D Fernald
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexander G OphirSteven M Phelps
Apr 29, 2008·Neuron·Caroline F ZinkAndreas Meyer-Lindenberg
Jul 18, 2008·Social Neuroscience·Naotaka FujiiAtsushi Iriki
Mar 23, 2010·Hormones and Behavior·Karen P Maruska, Russell D Fernald
Jul 29, 2010·Journal of Neurodevelopmental Disorders·Nadine GogollaTakao K Hensch
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Julie K DesjardinsRussell D Fernald
Oct 1, 2009·Integrative and Comparative Biology·Rui F Oliveira
Jul 14, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marjan TimmerCarmen Sandi
Jul 30, 2011·The Journal of Comparative Neurology·Lauren A O'Connell, Hans A Hofmann
Nov 15, 2011·Advances in Genetics·Ivan D Chase, Kristine Seitz
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Oct 9, 2012·Trends in Ecology & Evolution·Barbara Taborsky, Rui F Oliveira
Mar 26, 2014·General and Comparative Endocrinology·Lin S HuffmanHans A Hofmann
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rafał CzajkowskiAlcino J Silva
Aug 27, 2014·Trends in Ecology & Evolution·Hans A HofmannDustin R Rubenstein
Aug 28, 2014·Trends in Neurosciences·Fei WangHailan Hu
Sep 3, 2014·PLoS Biology·MaryAnn P NoonanMatthew F S Rushworth
Mar 10, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Russell D Fernald
May 21, 2015·Nature Reviews. Neuroscience·Philip TovoteAndreas Lüthi
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Noam ZerubavelKevin N Ochsner
Dec 5, 2015·Frontiers in Psychology·Lucy K BicksHirofumi Morishita

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Citations

Nov 30, 2019·The European Journal of Neuroscience·Emily C WrightBrian C Trainor
Oct 17, 2019·Frontiers in Behavioral Neuroscience·Olinda AlmeidaRui F Oliveira
Mar 27, 2021·Genes, Brain, and Behavior·Hannah D FulenwiderAndrey E Ryabinin
Jan 11, 2022·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T M MilewskiJ P Curley

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Software Mentioned

ImageJ
R package lattice
R
Allen Mouse Brain Atlas
R package lme4
RStudio
R package compete
pvclust
PlayerRatings

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