PMID: 8968192Dec 1, 1996Paper

Immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest

Anesthesiology
P M BokeschR M Kream

Abstract

Cardiopulmonary bypass (CPB) and hypothermic circulatory arrest (HCA) are associated with neurological injury. Altered immediate-early gene expression occurs rapidly in the brain in response to ischemia, hypoxia, and severe metabolic stress, which results in long-term changes in the molecular phenotype of neurons. This study determined the effects of CPB and HCA on the expression of the immediate-early gene c-fos. Neonatal lambs were subjected to 2 h of CPB at 38 degrees C (n = 4) or 60 min (n = 6), 90 min (n = 7), and 120 min (n = 6) of HCA at 15 degrees C. One hour after terminating CPB at 38 degrees C, the brains were analyzed for FOS-encoding mRNA and FOS-like immunoreactivity in the hippocampal formation. Other animals (n = 15), subjected to the same CPB and HCA protocol, were allowed to survive 3-5 days before their brains were examined for dead neurons. Minimal c-fos mRNA and FOS proteins were observed in neurons of animals subjected to normothermic bypass and of those that served as controls. Non-neuronal FOS proteins were observed in the choroid plexus, ependyma, and blood vessels at all times, including normothermic CPB, but not in the control animals without CPB. The magnitude of c-fos mRNA expression in hippocampal ...Continue Reading

References

Jan 1, 1992·Annual Review of Physiology·G P Gasic, M Hollmann
Jun 1, 1991·The Annals of Thoracic Surgery·M D CrittendenJ A Swain
Mar 1, 1990·American Journal of Diseases of Children·J R McConnellJ D Kugler
Jan 1, 1990·Stroke; a Journal of Cerebral Circulation·D O WiebersJ P Whisnant
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Dec 22, 1989·Science·J L SonnenbergT Curran
Sep 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P J StowJ G Coles
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jan 1, 1994·Brain Pathology·M Kiessling, P Gass

❮ Previous
Next ❯

Citations

Dec 5, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Su Dian-SanZhao Yan-Hua
Mar 3, 2004·Journal of the American College of Surgeons·Davida A RobinsonKenneth G Warner
Sep 24, 2010·The New England Journal of Medicine·Michael Holzer
May 29, 2004·Current Opinion in Critical Care·Christian Madl, Michael Holzer
Mar 29, 2000·The Annals of Thoracic Surgery·V S AbrahamM M Musulin
Apr 5, 2011·Clinical Biochemistry·Giuseppe LippiGianfranco Cervellin
Feb 24, 2009·Advanced Drug Delivery Reviews·Jian WuNipavan Chiamvimonvat
Sep 18, 2012·Journal of Cardiac Surgery·Qun GuShijiang Zhang
Nov 5, 1998·Journal of Cardiothoracic and Vascular Anesthesia·E B Mossad, P M Bokesch
Jul 16, 2014·Journal of Cardiovascular Medicine·Andrea PicchiGianfranco Gensini
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Michael HolzerUNKNOWN Hypothermia After Cardiac Arrest Study Group
Feb 24, 2001·Perfusion·H P GrocottD S Warner
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Bettina Jungwirth, Fellery de Lange

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.