Immediate early gene expression to examine neuronal activity following acute and chronic stressors in rat pups: examination of neurophysiological alterations underlying behavioral consequences of prenatal cocaine exposure

Physiology & Behavior
G A GoodwinL P Spear

Abstract

Altered behavioral responses to stressors have been observed in animals exposed to cocaine prenatally. In the present study, both behavioral and physiological responses to repeated and single stressor exposure were measured in animals prenatally exposed to cocaine. Offspring were derived from 3 prenatal treatment groups: dams that were administered 40 mg/kg cocaine from gestational day 8-20 (C40); dams that were pair-fed and -watered to weight-matched C40 dams (PF); and untreated dams (LCC). Starting on postnatal day 16-17 (P16-17), offspring from the 3 prenatal treatment groups were exposed to either footshock or isolation daily for 5 days. Two days after the last day of stressor exposure (P21-22), subjects were given 1 final exposure to the stressor to which they were previously exposed. In addition, at P21-22, littermates of animals given repeated exposure to stressors were exposed to either footshock or isolation for the first and only time. During all footshock sessions, the duration of freezing behavior was recorded. Plasma adrenocorticotrophin (ACTH) and corticosterone levels were determined from blood samples taken immediately following the final stressor session and brains were processed for C-FOS immunoreactivity (FOS...Continue Reading

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Citations

Apr 28, 2004·Neurotoxicity Research·C S PlanetaB E Kosofsky
Oct 16, 1999·Brain Research. Developmental Brain Research·P J LyssM H Teicher
Dec 20, 2000·Neurotoxicology and Teratology·J O CampbellL P Spear
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Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenBurt M Sharp
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Feb 1, 2005·Neurotoxicology and Teratology·Lynne S Hansen-Trench, Susan Barron

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