PMID: 22329546Feb 15, 2012Paper

Immediate early proto-oncoproteins and membranes: not just an innocent liaison

Current Protein & Peptide Science
Graciela A Borioli

Abstract

Proto-oncoproteins are a heterogeneous group of proteins that induce cellular differentiation, proliferation and growth, acting at different points of signaling cascades and in different cell compartments, through many different mechanisms. If the proto-oncogenes that give raise to proto-oncoproteins undergo genetic damage, they become oncogenes and their products are the oncoproteins responsible for cellular transformation in cancer. Some proto-oncoproteins are related to membranes and they exert their function at this level. Among these are receptors and receptor-like growth factors, membrane associated tyrosine kinases, and small GTPases. Other proto-oncoproteins are transcription factors and as such, their best known functional context is promoter DNA regions. Consequently, DNA is widely viewed as their most relevant non protein partner. Any interaction of these proteins with membranes is generally overlooked and, when considered, the membrane is regarded as a reservoir for timely release requiring proteolytic activity. However, this status quo should be revised. Some Immediate-Early proteins that are mobilized in the cell shortly after stimulus are also a subset of the transcription factor kind of proto-oncoproteins. These...Continue Reading

Citations

May 29, 2013·IUBMB Life·Andrés M Cardozo Gizzi, Beatriz L Caputto

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