Immediate effect of intensive atorvastatin therapy on lipid parameters in patients with acute coronary syndrome.

Lipids in Health and Disease
Dagmar VondrakovaAndreas Kruger

Abstract

Intensive statin therapy decreases mortality and incidence of coronary events in patients after acute coronary syndrome (ACS). Recently it has been reported that spontaneous lipid levels remain clinically stable during ACS. The immediate influence of lipid levels by high-dose statin therapy initiated at admission in ACS patients is, however, not clear. We have analyzed a group of 114 patients with ACS (mean age 63.7; females 25.4%). Atorvastatin 80 mg was administered at admission and then once daily for the rest of hospitalization. The levels of total cholesterol (TC), LDL-cholesterol (LDL), HDL-cholesterol (HDL), and triglycerides (TG) were measured at admission (D0), and then every morning of hospitalization (D1, D2). The mean entry values (D0) of TC, LDL, HDL and TG (in mmol/L) were 5.24, 3.26, 1.07 and 1.31, respectively. The therapy with atorvastatin 80 mg resulted in a decrease of TC levels in the first morning (D1) by 6.1% and in the second morning (D2) by 13.2% (p<0.001 for all comparisons with the entry value D0); LDL was decreased by 5.8% (D1) and 15.6% (D2) (p<0.001 vs. D0); the level of HDL was decreased by 7.5% (D1) and 12.1% (D2) (p<0.001 vs. D0). In contrast, the TG level was higher in the first morning (D1) by ...Continue Reading

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Citations

Nov 7, 2012·Current Treatment Options in Cardiovascular Medicine·Gautam Reddy, Vera Bittner
Dec 4, 2014·European Journal of Internal Medicine·Wei-Sheng ChungChia-Hung Kao
Feb 11, 2012·Canadian Journal of Physiology and Pharmacology·Tatyana A KorolenkoVassilij I Kaledin
Mar 15, 2015·International Journal of Cardiology·Wei-Sheng ChungChia-Hung Kao
Jan 24, 2015·QJM : Monthly Journal of the Association of Physicians·W-S ChungC-H Kao
Aug 14, 2013·International Journal of Cardiology·Wei-Sheng ChungChia-Hung Kao

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