Immediate functional effects of left ventricular reduction: a Doppler echocardiographic study in the rat

Journal of Cardiac Failure
Rosemeire M KanashiroPaulo J F Tucci

Abstract

Immediate functional effects of left ventricle reduction (LVR) are not yet fully defined. Those effects have been studied in the experimental model of myocardial infarction scar plication (MISP) in the rat. A Doppler echocardiogram was performed immediately before and after MISP in 20 rats with infarction of the left ventricle (LV) larger than 40%. LV diastolic volume reduction (475 +/- 114 versus 185 +/- 65 muL) was accompanied by heart rate decrease (230 +/- 25 versus 166 +/- 27 beats/min) and increase of ejection fraction (37 +/- 7 versus 67 +/- 12%), fractional shortening (18 +/- 3 versus 46 +/- 8%) and posterior wall shortening velocity (1.50 +/- 0.62 versus 2.01 +/- 0.46 cm/s). LV diastolic volume/stroke volume slope was steeper after LVR, suggesting enhancement of the Frank-Starling mechanism. Restrictive pattern of left atrial emptying was alleviated after LVR (E wave: 101 +/- 15 versus 66 +/- 14 cm/s; E/A ratio: 6.8 +/- 2.9 versus 5.0 +/- 2.2; E wave deceleration time: 36 +/- 6 versus 51 +/- 10 msec) even though left atrial diameter (0.69 +/- 0.07 versus 0.66 +/- 0.06 cm) and A wave (18.0 +/- 9.4 versus 15.8 +/- 7.8 cm/s) did not vary. Additionally, a pulmonary flow profile suggesting pulmonary hypertension was observe...Continue Reading

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Citations

Oct 20, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Luís Felipe Dos SantosGuilherme Fenelon
Nov 3, 2009·Journal of Cardiac Failure·Izo HelberPaulo J F Tucci
Apr 16, 2016·Canadian Journal of Physiology and Pharmacology·Núbia Mantovan FardinRuy R Campos
Nov 13, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Camila T PicolloPaulo J F Tucci
Apr 14, 2021·Lasers in Surgery and Medicine·Regiane Dos Santos FelicianoJosé Antônio Silva Júnior

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