PMID: 6108219Oct 1, 1980Paper

Immediate haemodynamic effects of prenalterol, a new adrenergic beta-1-receptor agonist, in healthy volunteers

European Journal of Clinical Pharmacology
T L SvendsenJ Trap-Jensen

Abstract

The acute haemodynamic effects of prenalterol, a selective adrenergic beta-1-receptor agonist, were studied in eight healthy male volunteers. Prenalterol was administered i.v. in five increasing doses to a cumulative dose of 5.55 mg. After the last dose of prenalterol, three doses of the selective adrenergic beta-1-receptor antagonist metoprolol were administered i.v. to a cumulative dose of 17.5 mg. After each dose, cardiac output (CO), stroke volume (SV), blood pressure (BP), heart rate (HR), systolic time intervals (STI) and forearm blood flow (FBF) were determined. Prenalterol had the following effects: CO was significantly increased by 21.0% after the fourth dose, but the fifth dose did not further change CO. SV was unchanged after the first four doses, but after the fifth dose a significant decrease in SV of 7.0% was seen. Mean BP was increased significantly by 7.7%, but diastolic BP remained unchanged. HR was increased by 28.4%. Total peripheral resistance was reduced by 8.8%. STI were reduced significantly after the second dose, which indicates that prenalterol has a positive inotropic action. FBF was increased significantly after the fourth dose. After the third dose of metoprolol, the CO, SV, means BP, HR, STI and FBF...Continue Reading

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
May 31, 1978·European Journal of Clinical Pharmacology·G JohnssonJ Wikstrand
Apr 1, 1979·British Journal of Clinical Pharmacology·D H ScottD B Scott
May 21, 1979·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Jan 4, 1979·The New England Journal of Medicine·E H SonnenblickT H LeJemtel
Jun 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·T HallböökR Nilsén
Apr 1, 1969·The American Journal of Cardiology·A M WeisslerC D Schoenfeld

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·E J SainsburyJ J Ashley
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Nov 1, 1987·British Journal of Clinical Pharmacology·P M McCaffreyR G Shanks

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